A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report
Key Clinical Message Idiopathic multicentric Castleman disease (iMCD) is challenging to diagnose due to clinical similarities with other conditions, such as Still's disease. Once diagnosed, iMCD may be effectively managed with the anti‐interleukin‐6 antibody siltuximab. Abstract Here, we presen...
| Главные авторы: | , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Wiley
2023-10-01
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| Серии: | Clinical Case Reports |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1002/ccr3.7981 |
| _version_ | 1827784265333473280 |
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| author | Magdalena Strach Piotr Kuszmiersz Łukasz Chmura Mariusz Korkosz |
| author_facet | Magdalena Strach Piotr Kuszmiersz Łukasz Chmura Mariusz Korkosz |
| author_sort | Magdalena Strach |
| collection | DOAJ |
| description | Key Clinical Message Idiopathic multicentric Castleman disease (iMCD) is challenging to diagnose due to clinical similarities with other conditions, such as Still's disease. Once diagnosed, iMCD may be effectively managed with the anti‐interleukin‐6 antibody siltuximab. Abstract Here, we present the case of a 19‐year‐old Polish woman with persistent fever and enlarged lymph nodes and whose diagnosis remained inconclusive following initial clinical assessments and extensive laboratory analyses. The patient had subsequent complaints of joint pain and erythema which were suspicious of Still's disease and resolved with treatment with tocilizumab. Later, the progression of symptoms, such as lymphadenopathy, and elevated interleukin‐6 levels were consistent with Castleman disease, leading to the diagnosis of idiopathic multicentric Castleman disease seven years after the patient first reported symptoms. Treatment with the anti‐interleukin‐6 antibody siltuximab resulted in complete symptom resolution and normalization of inflammatory parameters. No adverse events were reported due to treatment with siltuximab. |
| first_indexed | 2024-03-11T15:59:41Z |
| format | Article |
| id | doaj.art-323d0b51cefc46d5b0838d5ceb132a3c |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-11T15:59:41Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-323d0b51cefc46d5b0838d5ceb132a3c2023-10-25T07:12:45ZengWileyClinical Case Reports2050-09042023-10-011110n/an/a10.1002/ccr3.7981A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case reportMagdalena Strach0Piotr Kuszmiersz1Łukasz Chmura2Mariusz Korkosz3Department of Rheumatology and Immunology, Faculty of Medicine Jagiellonian University Medical College Kraków PolandDepartment of Rheumatology and Immunology, Faculty of Medicine Jagiellonian University Medical College Kraków PolandDepartment of Pathomorphology, Faculty of Medicine Jagiellonian University Medical College Kraków PolandDepartment of Rheumatology and Immunology, Faculty of Medicine Jagiellonian University Medical College Kraków PolandKey Clinical Message Idiopathic multicentric Castleman disease (iMCD) is challenging to diagnose due to clinical similarities with other conditions, such as Still's disease. Once diagnosed, iMCD may be effectively managed with the anti‐interleukin‐6 antibody siltuximab. Abstract Here, we present the case of a 19‐year‐old Polish woman with persistent fever and enlarged lymph nodes and whose diagnosis remained inconclusive following initial clinical assessments and extensive laboratory analyses. The patient had subsequent complaints of joint pain and erythema which were suspicious of Still's disease and resolved with treatment with tocilizumab. Later, the progression of symptoms, such as lymphadenopathy, and elevated interleukin‐6 levels were consistent with Castleman disease, leading to the diagnosis of idiopathic multicentric Castleman disease seven years after the patient first reported symptoms. Treatment with the anti‐interleukin‐6 antibody siltuximab resulted in complete symptom resolution and normalization of inflammatory parameters. No adverse events were reported due to treatment with siltuximab.https://doi.org/10.1002/ccr3.7981anti‐interleukin‐6 antibodycase reportdiagnosisidiopathic multicentric Castleman diseasesiltuximab |
| spellingShingle | Magdalena Strach Piotr Kuszmiersz Łukasz Chmura Mariusz Korkosz A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report Clinical Case Reports anti‐interleukin‐6 antibody case report diagnosis idiopathic multicentric Castleman disease siltuximab |
| title | A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report |
| title_full | A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report |
| title_fullStr | A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report |
| title_full_unstemmed | A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report |
| title_short | A challenging diagnosis of idiopathic multicentric Castleman disease with complex systemic presentation: A case report |
| title_sort | challenging diagnosis of idiopathic multicentric castleman disease with complex systemic presentation a case report |
| topic | anti‐interleukin‐6 antibody case report diagnosis idiopathic multicentric Castleman disease siltuximab |
| url | https://doi.org/10.1002/ccr3.7981 |
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