Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins
Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking pathways to form their unique replicative niches. To promote intracellular replication, the bacteria must interact with host organelles and modulate host signaling pathways to acquire nutrients and membran...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcell.2018.00001/full |
| _version_ | 1818381132136185856 |
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| author | Mary M. Weber Robert Faris |
| author_facet | Mary M. Weber Robert Faris |
| author_sort | Mary M. Weber |
| collection | DOAJ |
| description | Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking pathways to form their unique replicative niches. To promote intracellular replication, the bacteria must interact with host organelles and modulate host signaling pathways to acquire nutrients and membrane for the growing parasitophorous vacuole all while suppressing activation of the immune response. To facilitate host cell subversion, bacterial pathogens use specialized secretion systems to deliver bacterial virulence factors, termed effectors, into the host cell that mimic, agonize, and/or antagonize the function of host proteins. In this review we will discuss how bacterial effector proteins from Coxiella burnetii, Brucella abortus, Salmonella enterica serovar Typhimurium, Legionella pneumophila, Chlamydia trachomatis, and Orientia tsutsugamushi manipulate the endocytic and secretory pathways. Understanding how bacterial effector proteins manipulate host processes not only gives us keen insight into bacterial pathogenesis, but also enhances our understanding of how eukaryotic membrane trafficking is regulated. |
| first_indexed | 2024-12-14T02:29:43Z |
| format | Article |
| id | doaj.art-323dac25418c4e6980960e66ddd84479 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T02:29:43Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-323dac25418c4e6980960e66ddd844792022-12-21T23:20:17ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-01-01610.3389/fcell.2018.00001327878Subversion of the Endocytic and Secretory Pathways by Bacterial Effector ProteinsMary M. WeberRobert FarisIntracellular bacteria have developed numerous strategies to hijack host vesicular trafficking pathways to form their unique replicative niches. To promote intracellular replication, the bacteria must interact with host organelles and modulate host signaling pathways to acquire nutrients and membrane for the growing parasitophorous vacuole all while suppressing activation of the immune response. To facilitate host cell subversion, bacterial pathogens use specialized secretion systems to deliver bacterial virulence factors, termed effectors, into the host cell that mimic, agonize, and/or antagonize the function of host proteins. In this review we will discuss how bacterial effector proteins from Coxiella burnetii, Brucella abortus, Salmonella enterica serovar Typhimurium, Legionella pneumophila, Chlamydia trachomatis, and Orientia tsutsugamushi manipulate the endocytic and secretory pathways. Understanding how bacterial effector proteins manipulate host processes not only gives us keen insight into bacterial pathogenesis, but also enhances our understanding of how eukaryotic membrane trafficking is regulated.http://journal.frontiersin.org/article/10.3389/fcell.2018.00001/fullCoxiellaBrucellaSalmonellaLegionellaChlamydiaOrientia |
| spellingShingle | Mary M. Weber Robert Faris Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins Frontiers in Cell and Developmental Biology Coxiella Brucella Salmonella Legionella Chlamydia Orientia |
| title | Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins |
| title_full | Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins |
| title_fullStr | Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins |
| title_full_unstemmed | Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins |
| title_short | Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins |
| title_sort | subversion of the endocytic and secretory pathways by bacterial effector proteins |
| topic | Coxiella Brucella Salmonella Legionella Chlamydia Orientia |
| url | http://journal.frontiersin.org/article/10.3389/fcell.2018.00001/full |
| work_keys_str_mv | AT marymweber subversionoftheendocyticandsecretorypathwaysbybacterialeffectorproteins AT robertfaris subversionoftheendocyticandsecretorypathwaysbybacterialeffectorproteins |