Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery

Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery

Objectives: During dengue fever, a pronounced gamma-interferon immune response produces neopterin and promotes tryptophan degradation by the enzyme indoleamine-2,3-dioxygenase 1 (IDO-1). Activated IDO-1 is indicated by an increased kynurenine to tryptophan ratio (Kyn/Trp) in patients. Methods: Plasm...

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Bibliographic Details
Main Authors: Simon Geisler, Simon D. Lytton, Nguyen Linh Toan, Trinh Huu Nghia, Nguyen Minh Nam, Hoang Vu Hung, Nguyen Thai Son, Do Tuan Anh, Hoang Tien Tuyen, Tran Viet Tien, Do Quyet, Hoang Van Tong, Nghiem Xuan Hoan, Le Huu Song, Srinivas Reddy Pallerla, Johanna M. Gostner, Dietmar Fuchs, Thirumalaisamy P. Velavan
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971219304783

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