Mediating the death of dormant tumor cells
How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1458013 |
| _version_ | 1797677136614522880 |
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| author | Yuying Liu Jiadi Lv Bo Huang |
| author_facet | Yuying Liu Jiadi Lv Bo Huang |
| author_sort | Yuying Liu |
| collection | DOAJ |
| description | How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon receptor (AhR)-cyclin-dependent kinase inhibitor 1B (p27) pathway, while blocking this pathway leads dormant TRCs to apoptosis by switching to STAT3-cellular tumor antigen p53 (p53) pathway. |
| first_indexed | 2024-03-11T22:40:34Z |
| format | Article |
| id | doaj.art-323f21cd8645478baeae8a756d126bc9 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:34Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-323f21cd8645478baeae8a756d126bc92023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-07-015410.1080/23723556.2018.14580131458013Mediating the death of dormant tumor cellsYuying Liu0Jiadi Lv1Bo Huang2Chinese Academy of Medical SciencesChinese Academy of Medical SciencesChinese Academy of Medical SciencesHow immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon receptor (AhR)-cyclin-dependent kinase inhibitor 1B (p27) pathway, while blocking this pathway leads dormant TRCs to apoptosis by switching to STAT3-cellular tumor antigen p53 (p53) pathway.http://dx.doi.org/10.1080/23723556.2018.1458013tumor-repopulating cellstumor dormancyimmune cytokineindoleamine-pyrrole 2,3-dioxygenasekynureninearyl hydrocarbon receptor |
| spellingShingle | Yuying Liu Jiadi Lv Bo Huang Mediating the death of dormant tumor cells Molecular & Cellular Oncology tumor-repopulating cells tumor dormancy immune cytokine indoleamine-pyrrole 2,3-dioxygenase kynurenine aryl hydrocarbon receptor |
| title | Mediating the death of dormant tumor cells |
| title_full | Mediating the death of dormant tumor cells |
| title_fullStr | Mediating the death of dormant tumor cells |
| title_full_unstemmed | Mediating the death of dormant tumor cells |
| title_short | Mediating the death of dormant tumor cells |
| title_sort | mediating the death of dormant tumor cells |
| topic | tumor-repopulating cells tumor dormancy immune cytokine indoleamine-pyrrole 2,3-dioxygenase kynurenine aryl hydrocarbon receptor |
| url | http://dx.doi.org/10.1080/23723556.2018.1458013 |
| work_keys_str_mv | AT yuyingliu mediatingthedeathofdormanttumorcells AT jiadilv mediatingthedeathofdormanttumorcells AT bohuang mediatingthedeathofdormanttumorcells |