Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1
Two new succinimide-containing derivatives, cladosporitins A (<b>1</b>) and B (<b>2</b>), were isolated from the fermentation cultures of the mangrove-derived fungus <i>Cladosporium</i> sp. HNWSW-1, along with a new pyrone, clapone (<b>3</b>), as well...
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/1/4 |
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| author | Pei Wang Yan Cui Caihong Cai Huiqin Chen Yu Dai Pengwei Chen Fandong Kong Jingzhe Yuan Xinming Song Wenli Mei Haofu Dai |
| author_facet | Pei Wang Yan Cui Caihong Cai Huiqin Chen Yu Dai Pengwei Chen Fandong Kong Jingzhe Yuan Xinming Song Wenli Mei Haofu Dai |
| author_sort | Pei Wang |
| collection | DOAJ |
| description | Two new succinimide-containing derivatives, cladosporitins A (<b>1</b>) and B (<b>2</b>), were isolated from the fermentation cultures of the mangrove-derived fungus <i>Cladosporium</i> sp. HNWSW-1, along with a new pyrone, clapone (<b>3</b>), as well as the previously reported talaroconvolutin A (<b>4</b>) and anthraquinone (<b>5</b>). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound <b>2</b> showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC<sub>50</sub> values of 29.4 ± 0.35 μM, 25.6 ± 0.47 μM, and 41.7 ± 0.71 μM, respectively, whereas compound <b>4</b> exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC<sub>50</sub> values of 14.9 ± 0.21 μM and 26.7 ± 1.1 μM, respectively. In addition, compounds <b>4</b> and <b>5</b> displayed inhibitory activity against α-glycosidase, with IC<sub>50</sub> values of 78.2 ± 2.1 μM and 49.3 ± 10.6 μM, respectively. |
| first_indexed | 2024-04-11T11:13:48Z |
| format | Article |
| id | doaj.art-32401b02b2f84c24acd418035eb1332e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T11:13:48Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-32401b02b2f84c24acd418035eb1332e2022-12-22T04:27:17ZengMDPI AGMarine Drugs1660-33972018-12-01171410.3390/md17010004md17010004Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1Pei Wang0Yan Cui1Caihong Cai2Huiqin Chen3Yu Dai4Pengwei Chen5Fandong Kong6Jingzhe Yuan7Xinming Song8Wenli Mei9Haofu Dai10Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education and Hainan Normal University, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaTwo new succinimide-containing derivatives, cladosporitins A (<b>1</b>) and B (<b>2</b>), were isolated from the fermentation cultures of the mangrove-derived fungus <i>Cladosporium</i> sp. HNWSW-1, along with a new pyrone, clapone (<b>3</b>), as well as the previously reported talaroconvolutin A (<b>4</b>) and anthraquinone (<b>5</b>). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound <b>2</b> showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC<sub>50</sub> values of 29.4 ± 0.35 μM, 25.6 ± 0.47 μM, and 41.7 ± 0.71 μM, respectively, whereas compound <b>4</b> exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC<sub>50</sub> values of 14.9 ± 0.21 μM and 26.7 ± 1.1 μM, respectively. In addition, compounds <b>4</b> and <b>5</b> displayed inhibitory activity against α-glycosidase, with IC<sub>50</sub> values of 78.2 ± 2.1 μM and 49.3 ± 10.6 μM, respectively.https://www.mdpi.com/1660-3397/17/1/4mangrove-derived fungus<i>Cladosporium</i> sp.succinimide-containing derivativescytotoxicityα-glycosidase inhibitor |
| spellingShingle | Pei Wang Yan Cui Caihong Cai Huiqin Chen Yu Dai Pengwei Chen Fandong Kong Jingzhe Yuan Xinming Song Wenli Mei Haofu Dai Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 Marine Drugs mangrove-derived fungus <i>Cladosporium</i> sp. succinimide-containing derivatives cytotoxicity α-glycosidase inhibitor |
| title | Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 |
| title_full | Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 |
| title_fullStr | Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 |
| title_full_unstemmed | Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 |
| title_short | Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus <i>Cladosporium</i> sp. HNWSW-1 |
| title_sort | two new succinimide derivatives cladosporitins a and b from the mangrove derived fungus i cladosporium i sp hnwsw 1 |
| topic | mangrove-derived fungus <i>Cladosporium</i> sp. succinimide-containing derivatives cytotoxicity α-glycosidase inhibitor |
| url | https://www.mdpi.com/1660-3397/17/1/4 |
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