Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study
Abstract Background Spot-check hemoglobin co-oximetry analyzers measure hemoglobin transcutaneously and offer the benefit of a hemoglobin measurement without phlebotomy. The objective of this study was to determine the validity of non-invasive spot-check hemoglobin co-oximetry testing for the detect...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05783-3 |
| _version_ | 1797789484257902592 |
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| author | Kienna Mills Julie M. Vermeer Warren E. Berry Erwin Karreman Christine D. Lett |
| author_facet | Kienna Mills Julie M. Vermeer Warren E. Berry Erwin Karreman Christine D. Lett |
| author_sort | Kienna Mills |
| collection | DOAJ |
| description | Abstract Background Spot-check hemoglobin co-oximetry analyzers measure hemoglobin transcutaneously and offer the benefit of a hemoglobin measurement without phlebotomy. The objective of this study was to determine the validity of non-invasive spot-check hemoglobin co-oximetry testing for the detection of postpartum anemia (hemoglobin < 10 g/dL). Methods Five hundred eighty-four women aged 18 and over were recruited on postpartum day one following a singleton delivery. Two non-invasive spot-check hemoglobin co-oximetry monitors, Masimo Pronto Pulse CO-Oximeter (Pronto) and Masimo Rad-67 Pulse CO-Oximeter (Rad-67), were evaluated and compared to the postpartum phlebotomy hemoglobin value. Results Of 584 participants, 31% (181) had postpartum anemia by phlebotomy hemoglobin measurement. Bland–Altman plots determined a bias of + 2.4 (± 1.2) g/dL with the Pronto and + 2.2 (± 1.1) g/dL with the Rad-67. Low sensitivity was observed: 15% for the Pronto and 16% for the Rad-67. Adjusting for the fixed bias, the Pronto demonstrated a sensitivity of 68% and specificity of 84%, while the Rad-67 demonstrated a sensitivity of 78% and specificity of 88%. Conclusion A consistent overestimation of hemoglobin by the non-invasive spot-check hemoglobin co-oximetry monitors compared to phlebotomy hemoglobin result was observed. Even after adjusting for the fixed bias, the sensitivity for detecting postpartum anemia was low. Detection of postpartum anemia should not be based on these devices alone. |
| first_indexed | 2024-03-13T01:51:19Z |
| format | Article |
| id | doaj.art-32408ef5237140ea9388c9d30ba2f577 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-13T01:51:19Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-32408ef5237140ea9388c9d30ba2f5772023-07-02T11:29:24ZengBMCBMC Pregnancy and Childbirth1471-23932023-06-012311910.1186/s12884-023-05783-3Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort studyKienna Mills0Julie M. Vermeer1Warren E. Berry2Erwin Karreman3Christine D. Lett4Health Science Building, University of SaskatchewanDepartment of Obstetrics and Gynecology, University of Saskatchewan, Reginal General HospitalSaskatchewan Health AuthoritySaskatchewan Health AuthorityDepartment of Obstetrics and Gynecology, University of Saskatchewan, Reginal General HospitalAbstract Background Spot-check hemoglobin co-oximetry analyzers measure hemoglobin transcutaneously and offer the benefit of a hemoglobin measurement without phlebotomy. The objective of this study was to determine the validity of non-invasive spot-check hemoglobin co-oximetry testing for the detection of postpartum anemia (hemoglobin < 10 g/dL). Methods Five hundred eighty-four women aged 18 and over were recruited on postpartum day one following a singleton delivery. Two non-invasive spot-check hemoglobin co-oximetry monitors, Masimo Pronto Pulse CO-Oximeter (Pronto) and Masimo Rad-67 Pulse CO-Oximeter (Rad-67), were evaluated and compared to the postpartum phlebotomy hemoglobin value. Results Of 584 participants, 31% (181) had postpartum anemia by phlebotomy hemoglobin measurement. Bland–Altman plots determined a bias of + 2.4 (± 1.2) g/dL with the Pronto and + 2.2 (± 1.1) g/dL with the Rad-67. Low sensitivity was observed: 15% for the Pronto and 16% for the Rad-67. Adjusting for the fixed bias, the Pronto demonstrated a sensitivity of 68% and specificity of 84%, while the Rad-67 demonstrated a sensitivity of 78% and specificity of 88%. Conclusion A consistent overestimation of hemoglobin by the non-invasive spot-check hemoglobin co-oximetry monitors compared to phlebotomy hemoglobin result was observed. Even after adjusting for the fixed bias, the sensitivity for detecting postpartum anemia was low. Detection of postpartum anemia should not be based on these devices alone.https://doi.org/10.1186/s12884-023-05783-3PostpartumAnemiaNon-invasive hemoglobin measurementSpot-check hemoglobin co-oximetryPatient blood management |
| spellingShingle | Kienna Mills Julie M. Vermeer Warren E. Berry Erwin Karreman Christine D. Lett Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study BMC Pregnancy and Childbirth Postpartum Anemia Non-invasive hemoglobin measurement Spot-check hemoglobin co-oximetry Patient blood management |
| title | Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study |
| title_full | Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study |
| title_fullStr | Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study |
| title_full_unstemmed | Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study |
| title_short | Determining the validity of non-invasive spot-check hemoglobin co-oximetry testing to detect anemia in postpartum women at a tertiary care centre, a prospective cohort study |
| title_sort | determining the validity of non invasive spot check hemoglobin co oximetry testing to detect anemia in postpartum women at a tertiary care centre a prospective cohort study |
| topic | Postpartum Anemia Non-invasive hemoglobin measurement Spot-check hemoglobin co-oximetry Patient blood management |
| url | https://doi.org/10.1186/s12884-023-05783-3 |
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