Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves
This research reported a hydrogel loaded with the ethanolic and methanolic extracts of <i>Eupatorium glutinosum</i> Lam. The <i>E. glutinosum</i> extracts were characterized by phytochemical screening, Fourier-transform infrared spectroscopy (FTIR), thin-layer chromatography...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/4/1591 |
| _version_ | 1797619081065529344 |
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| author | Lizbeth Zamora-Mendoza Santiago Nelson Vispo Lola De Lima José R. Mora António Machado Frank Alexis |
| author_facet | Lizbeth Zamora-Mendoza Santiago Nelson Vispo Lola De Lima José R. Mora António Machado Frank Alexis |
| author_sort | Lizbeth Zamora-Mendoza |
| collection | DOAJ |
| description | This research reported a hydrogel loaded with the ethanolic and methanolic extracts of <i>Eupatorium glutinosum</i> Lam. The <i>E. glutinosum</i> extracts were characterized by phytochemical screening, Fourier-transform infrared spectroscopy (FTIR), thin-layer chromatography (TLC), and UV/Vis profile identification. This research also evaluated the pharmacological activity of the extracts using antimicrobial, antioxidant, and anti-inflammatory assays prior to polymeric encapsulation. Results indicate that extracts inhibit the <i>Escherichia colii</i> DH5-α (Gram negative) growth; excellent antioxidant activity was evaluated by the ferric reducing power and total antioxidant activity assays, and extracts showed an anti-hemolytic effect. Moreover, the cotton and microcrystalline cellulose hydrogels demonstrate successful encapsulation based on characterization and kinetics studies such as FTIR, extract release, and swelling degree. Moreover, effective antibacterial activity was registered by the loaded hydrogel. The overall results encourage and show that <i>Eupatorium glutinosum</i>-loaded hydrogel may find a wide range of bandage and wound healing applications in the biomedical area. |
| first_indexed | 2024-03-11T08:21:55Z |
| format | Article |
| id | doaj.art-32421d2f746d4705b96bf24bb5a09598 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T08:21:55Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-32421d2f746d4705b96bf24bb5a095982023-11-16T22:20:34ZengMDPI AGMolecules1420-30492023-02-01284159110.3390/molecules28041591Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. LeavesLizbeth Zamora-Mendoza0Santiago Nelson Vispo1Lola De Lima2José R. Mora3António Machado4Frank Alexis5School of Biological Sciences & Engineering, Yachay Tech University, Urcuquí 100119, EcuadorSchool of Biological Sciences & Engineering, Yachay Tech University, Urcuquí 100119, EcuadorSchool of Chemical Sciences and Engineering, Yachay Tech University, Urcuquí 100119, EcuadorDepartamento de Ingeniería Química, Colegio de Ciencias e Ingenierías, Universidad San Francisco de Quito (USFQ), Quito 170901, EcuadorLaboratorio de Bacteriología, Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales (COCIBA), Universidad San Francisco de Quito (USFQ), Quito 170901, EcuadorDepartamento de Ingeniería Química, Colegio de Ciencias e Ingenierías, Universidad San Francisco de Quito (USFQ), Quito 170901, EcuadorThis research reported a hydrogel loaded with the ethanolic and methanolic extracts of <i>Eupatorium glutinosum</i> Lam. The <i>E. glutinosum</i> extracts were characterized by phytochemical screening, Fourier-transform infrared spectroscopy (FTIR), thin-layer chromatography (TLC), and UV/Vis profile identification. This research also evaluated the pharmacological activity of the extracts using antimicrobial, antioxidant, and anti-inflammatory assays prior to polymeric encapsulation. Results indicate that extracts inhibit the <i>Escherichia colii</i> DH5-α (Gram negative) growth; excellent antioxidant activity was evaluated by the ferric reducing power and total antioxidant activity assays, and extracts showed an anti-hemolytic effect. Moreover, the cotton and microcrystalline cellulose hydrogels demonstrate successful encapsulation based on characterization and kinetics studies such as FTIR, extract release, and swelling degree. Moreover, effective antibacterial activity was registered by the loaded hydrogel. The overall results encourage and show that <i>Eupatorium glutinosum</i>-loaded hydrogel may find a wide range of bandage and wound healing applications in the biomedical area.https://www.mdpi.com/1420-3049/28/4/1591controlled delivery systemantioxidant activityanti-hemolytic activityantibacterial activitysecondary metabolites |
| spellingShingle | Lizbeth Zamora-Mendoza Santiago Nelson Vispo Lola De Lima José R. Mora António Machado Frank Alexis Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves Molecules controlled delivery system antioxidant activity anti-hemolytic activity antibacterial activity secondary metabolites |
| title | Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves |
| title_full | Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves |
| title_fullStr | Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves |
| title_full_unstemmed | Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves |
| title_short | Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of <i>Eupatorium glutinosum</i> Lam. Leaves |
| title_sort | hydrogel for the controlled delivery of bioactive components from extracts of i eupatorium glutinosum i lam leaves |
| topic | controlled delivery system antioxidant activity anti-hemolytic activity antibacterial activity secondary metabolites |
| url | https://www.mdpi.com/1420-3049/28/4/1591 |
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