Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series
Acute necrotizing encephalopathy of childhood (ANEC) is a potentially devastating illness characterized by fever, acute encephalopathy, and bilateral thalamic lesions. This case series is a retrospective review of clinical, laboratory, neuroimaging data of 19 children diagnosed with ANEC over 9 year...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Journal of Pediatric Critical Care |
| Subjects: | |
| Online Access: | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2021;volume=8;issue=4;spage=192;epage=196;aulast=Gupta |
| _version_ | 1818455801379946496 |
|---|---|
| author | Sandip Gupta Bidisha Banerjee Sruthi K Sasidharan Ullas V Acharya |
| author_facet | Sandip Gupta Bidisha Banerjee Sruthi K Sasidharan Ullas V Acharya |
| author_sort | Sandip Gupta |
| collection | DOAJ |
| description | Acute necrotizing encephalopathy of childhood (ANEC) is a potentially devastating illness characterized by fever, acute encephalopathy, and bilateral thalamic lesions. This case series is a retrospective review of clinical, laboratory, neuroimaging data of 19 children diagnosed with ANEC over 9 years at a single-center from south India. The median age was 84 months (interquartile range 25.5–120 months). All children had acute febrile encephalopathy, 12 had seizures and hypotension each, 8 had vomiting, and 5 had abnormal posturing. The liver transaminases were raised almost all children. All had bilateral thalamic lesions followed by lesions in cerebral white-matter, brain stem, and cerebellar white matter. Microbial etiology was established in 9 patients (7 dengue, 1 H1N1, 1 influenza A). Neurodeficits at discharge were seen in 63% and at follow-up in 33.3% cases. Neurodeficits at follow-up were seen in all cases with age <48 months, and only 11.1% with age >48 months age (P = 0.018). |
| first_indexed | 2024-12-14T22:16:33Z |
| format | Article |
| id | doaj.art-32462aff2fe849538eaf5db7b4fb4344 |
| institution | Directory Open Access Journal |
| issn | 2349-6592 2455-7099 |
| language | English |
| last_indexed | 2024-12-14T22:16:33Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pediatric Critical Care |
| spelling | doaj.art-32462aff2fe849538eaf5db7b4fb43442022-12-21T22:45:36ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992021-01-018419219610.4103/jpcc.jpcc_4_21Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case seriesSandip GuptaBidisha BanerjeeSruthi K SasidharanUllas V AcharyaAcute necrotizing encephalopathy of childhood (ANEC) is a potentially devastating illness characterized by fever, acute encephalopathy, and bilateral thalamic lesions. This case series is a retrospective review of clinical, laboratory, neuroimaging data of 19 children diagnosed with ANEC over 9 years at a single-center from south India. The median age was 84 months (interquartile range 25.5–120 months). All children had acute febrile encephalopathy, 12 had seizures and hypotension each, 8 had vomiting, and 5 had abnormal posturing. The liver transaminases were raised almost all children. All had bilateral thalamic lesions followed by lesions in cerebral white-matter, brain stem, and cerebellar white matter. Microbial etiology was established in 9 patients (7 dengue, 1 H1N1, 1 influenza A). Neurodeficits at discharge were seen in 63% and at follow-up in 33.3% cases. Neurodeficits at follow-up were seen in all cases with age <48 months, and only 11.1% with age >48 months age (P = 0.018).http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2021;volume=8;issue=4;spage=192;epage=196;aulast=Guptaacute necrotizing encephalopathy of childhoodneuroimagingneurologic outcomesteroids |
| spellingShingle | Sandip Gupta Bidisha Banerjee Sruthi K Sasidharan Ullas V Acharya Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series Journal of Pediatric Critical Care acute necrotizing encephalopathy of childhood neuroimaging neurologic outcome steroids |
| title | Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series |
| title_full | Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series |
| title_fullStr | Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series |
| title_full_unstemmed | Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series |
| title_short | Clinical, laboratory, radiologic profile, and outcome in acute necrotizing encephalopathy of childhood (ANEC) – A case series |
| title_sort | clinical laboratory radiologic profile and outcome in acute necrotizing encephalopathy of childhood anec a case series |
| topic | acute necrotizing encephalopathy of childhood neuroimaging neurologic outcome steroids |
| url | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2021;volume=8;issue=4;spage=192;epage=196;aulast=Gupta |
| work_keys_str_mv | AT sandipgupta clinicallaboratoryradiologicprofileandoutcomeinacutenecrotizingencephalopathyofchildhoodanecacaseseries AT bidishabanerjee clinicallaboratoryradiologicprofileandoutcomeinacutenecrotizingencephalopathyofchildhoodanecacaseseries AT sruthiksasidharan clinicallaboratoryradiologicprofileandoutcomeinacutenecrotizingencephalopathyofchildhoodanecacaseseries AT ullasvacharya clinicallaboratoryradiologicprofileandoutcomeinacutenecrotizingencephalopathyofchildhoodanecacaseseries |