Changing Radiotherapy Paradigms in Penile Cancer
Radiation therapy (RT) has not been prominent in the treatment of penile cancer because of poorly reproducible results when used in the adjuvant setting. A genomic signature has recently been described that assays radiosensitivity of tumors and informs radiotherapy doses in these cases. Clinical val...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | European Urology Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666168321033978 |
| _version_ | 1828125700480040960 |
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| author | Peter A.S. Johnstone Philippe E. Spiess Geoff Sedor G. Daniel Grass Kosj Yamoah Jacob G. Scott Javier F. Torres-Roca |
| author_facet | Peter A.S. Johnstone Philippe E. Spiess Geoff Sedor G. Daniel Grass Kosj Yamoah Jacob G. Scott Javier F. Torres-Roca |
| author_sort | Peter A.S. Johnstone |
| collection | DOAJ |
| description | Radiation therapy (RT) has not been prominent in the treatment of penile cancer because of poorly reproducible results when used in the adjuvant setting. A genomic signature has recently been described that assays radiosensitivity of tumors and informs radiotherapy doses in these cases. Clinical validation in more than 1600 patients demonstrated associations with both overall survival and time to first recurrence. In addition, the signature predicted and quantified the therapeutic benefit of RT for each individual patient. Since penile cancer patients were not part of this analysis, we applied the model to patients with primary and nodal penile cancer tissue and clinical outcomes.Patient summary: Radiotherapy has not been widely used for treatment of penile cancer. New genetic data suggest that radiation doses commonly used to treat penile cancer are too low. This would explain prior poor results using radiation in this disease. |
| first_indexed | 2024-04-11T15:24:29Z |
| format | Article |
| id | doaj.art-3246b3b232724f11b014157b7618fb4a |
| institution | Directory Open Access Journal |
| issn | 2666-1683 |
| language | English |
| last_indexed | 2024-04-11T15:24:29Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Urology Open Science |
| spelling | doaj.art-3246b3b232724f11b014157b7618fb4a2022-12-22T04:16:18ZengElsevierEuropean Urology Open Science2666-16832022-02-01364748Changing Radiotherapy Paradigms in Penile CancerPeter A.S. Johnstone0Philippe E. Spiess1Geoff Sedor2G. Daniel Grass3Kosj Yamoah4Jacob G. Scott5Javier F. Torres-Roca6Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Corresponding author at: Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA. Tel.: +1 813 7451075; Fax: +1 813 7457231.Moffitt Cancer Center and Research Institute, Tampa, FL, USACleveland Clinic, Cleveland, OH, USAMoffitt Cancer Center and Research Institute, Tampa, FL, USAMoffitt Cancer Center and Research Institute, Tampa, FL, USACleveland Clinic, Cleveland, OH, USAMoffitt Cancer Center and Research Institute, Tampa, FL, USARadiation therapy (RT) has not been prominent in the treatment of penile cancer because of poorly reproducible results when used in the adjuvant setting. A genomic signature has recently been described that assays radiosensitivity of tumors and informs radiotherapy doses in these cases. Clinical validation in more than 1600 patients demonstrated associations with both overall survival and time to first recurrence. In addition, the signature predicted and quantified the therapeutic benefit of RT for each individual patient. Since penile cancer patients were not part of this analysis, we applied the model to patients with primary and nodal penile cancer tissue and clinical outcomes.Patient summary: Radiotherapy has not been widely used for treatment of penile cancer. New genetic data suggest that radiation doses commonly used to treat penile cancer are too low. This would explain prior poor results using radiation in this disease.http://www.sciencedirect.com/science/article/pii/S2666168321033978Penile cancerRadiation sensitivityRadiation |
| spellingShingle | Peter A.S. Johnstone Philippe E. Spiess Geoff Sedor G. Daniel Grass Kosj Yamoah Jacob G. Scott Javier F. Torres-Roca Changing Radiotherapy Paradigms in Penile Cancer European Urology Open Science Penile cancer Radiation sensitivity Radiation |
| title | Changing Radiotherapy Paradigms in Penile Cancer |
| title_full | Changing Radiotherapy Paradigms in Penile Cancer |
| title_fullStr | Changing Radiotherapy Paradigms in Penile Cancer |
| title_full_unstemmed | Changing Radiotherapy Paradigms in Penile Cancer |
| title_short | Changing Radiotherapy Paradigms in Penile Cancer |
| title_sort | changing radiotherapy paradigms in penile cancer |
| topic | Penile cancer Radiation sensitivity Radiation |
| url | http://www.sciencedirect.com/science/article/pii/S2666168321033978 |
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