Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance
Saber Yezli,1 Yara Yassin,1 Abdulaziz Mushi,1 Mamdouh Bukhari,2 Talib Banasser,2 Anas Khan1,3 1The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; 2Regional Laboratory, Makkah City General Directorate of Health Affairs, Ministry of Health, Makkah, Saudi Arabia;...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/carriage-of-neisseria-meningitidis-among-umrah-pilgrims-circulating-se-peer-reviewed-fulltext-article-IDR |
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| author | Yezli S Yassin Y Mushi A Bukhari M Banasser T Khan A |
| author_facet | Yezli S Yassin Y Mushi A Bukhari M Banasser T Khan A |
| author_sort | Yezli S |
| collection | DOAJ |
| description | Saber Yezli,1 Yara Yassin,1 Abdulaziz Mushi,1 Mamdouh Bukhari,2 Talib Banasser,2 Anas Khan1,3 1The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; 2Regional Laboratory, Makkah City General Directorate of Health Affairs, Ministry of Health, Makkah, Saudi Arabia; 3Department of Emergency Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Saber Yezli, Global Centre for Mass Gatherings Medicine, Public Health Directorate, Ministry of Health, Riyadh, Saudi Arabia, Tel +96611401555 ext 1863, Email saber.yezli@gmail.comBackground: Meningococcal disease and outbreaks are a risk during mass gatherings such as the Umrah religious pilgrimage to the Kingdom of Saudi Arabia (KSA). We aimed to investigate the carriage of Neisseria meningitidis among the 2019 Umrah pilgrims and determine the circulating serogroups and their antibiotic susceptibility profiles.Methods: We conducted a cross-sectional study among adult Umrah pilgrims from 17th to 29th April 2019 in Mecca city, KSA. A questionnaire was administered to each participant, and an oropharyngeal swab was obtained. Microbiological techniques were used to isolate, identify and serogroup N. meningitidis from the swabs. E-tests were used to determine the susceptibility of the isolates to nine antibiotics.Results: The study enrolled 616 pilgrims from 17 countries with a mean age of 53.8 years (± 13.1, range = 19– 91) and a male-to-female ratio of 1.1:1. Nearly 39% of the respondents had no formal education, 32.5% declared having an underlying health condition and 17.2% were current or past smokers. During their Umrah stay, most pilgrims reported sharing accommodation (98.5%) and never using a face mask (98.5%). Also, 34.6% reported suffering from influenza-like symptoms and 11.8% used antibiotics. N. meningitidis was isolated from three pilgrims (carriage rate of 0.49%), two were serogroup A and one was serogroup B. Antibiotic susceptibility results were available for one isolate (serogroup B) which showed resistance to ciprofloxacin and decreased susceptibility to trimethoprim-sulfamethoxazole.Conclusion: Carriage of N. meningitidis among Umrah pilgrims was low. However, invasive serogroups were identified, including an isolate resistant to ciprofloxacin used for chemoprophylaxis. Meningococcal disease preventive measures for Umrah should be regularly reviewed and updated accordingly to reduce the risk of the disease and future pilgrimage-associated outbreaks.Keywords: mass gatherings, meningococcal disease, antibiotic resistance, public health, vaccine |
| first_indexed | 2024-12-11T00:03:51Z |
| format | Article |
| id | doaj.art-3247950bb52841e0bbc24f135c7604d5 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T00:03:51Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-3247950bb52841e0bbc24f135c7604d52022-12-22T01:28:22ZengDove Medical PressInfection and Drug Resistance1178-69732022-08-01Volume 154685469677576Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic ResistanceYezli SYassin YMushi ABukhari MBanasser TKhan ASaber Yezli,1 Yara Yassin,1 Abdulaziz Mushi,1 Mamdouh Bukhari,2 Talib Banasser,2 Anas Khan1,3 1The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; 2Regional Laboratory, Makkah City General Directorate of Health Affairs, Ministry of Health, Makkah, Saudi Arabia; 3Department of Emergency Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Saber Yezli, Global Centre for Mass Gatherings Medicine, Public Health Directorate, Ministry of Health, Riyadh, Saudi Arabia, Tel +96611401555 ext 1863, Email saber.yezli@gmail.comBackground: Meningococcal disease and outbreaks are a risk during mass gatherings such as the Umrah religious pilgrimage to the Kingdom of Saudi Arabia (KSA). We aimed to investigate the carriage of Neisseria meningitidis among the 2019 Umrah pilgrims and determine the circulating serogroups and their antibiotic susceptibility profiles.Methods: We conducted a cross-sectional study among adult Umrah pilgrims from 17th to 29th April 2019 in Mecca city, KSA. A questionnaire was administered to each participant, and an oropharyngeal swab was obtained. Microbiological techniques were used to isolate, identify and serogroup N. meningitidis from the swabs. E-tests were used to determine the susceptibility of the isolates to nine antibiotics.Results: The study enrolled 616 pilgrims from 17 countries with a mean age of 53.8 years (± 13.1, range = 19– 91) and a male-to-female ratio of 1.1:1. Nearly 39% of the respondents had no formal education, 32.5% declared having an underlying health condition and 17.2% were current or past smokers. During their Umrah stay, most pilgrims reported sharing accommodation (98.5%) and never using a face mask (98.5%). Also, 34.6% reported suffering from influenza-like symptoms and 11.8% used antibiotics. N. meningitidis was isolated from three pilgrims (carriage rate of 0.49%), two were serogroup A and one was serogroup B. Antibiotic susceptibility results were available for one isolate (serogroup B) which showed resistance to ciprofloxacin and decreased susceptibility to trimethoprim-sulfamethoxazole.Conclusion: Carriage of N. meningitidis among Umrah pilgrims was low. However, invasive serogroups were identified, including an isolate resistant to ciprofloxacin used for chemoprophylaxis. Meningococcal disease preventive measures for Umrah should be regularly reviewed and updated accordingly to reduce the risk of the disease and future pilgrimage-associated outbreaks.Keywords: mass gatherings, meningococcal disease, antibiotic resistance, public health, vaccinehttps://www.dovepress.com/carriage-of-neisseria-meningitidis-among-umrah-pilgrims-circulating-se-peer-reviewed-fulltext-article-IDRmass gatheringsmeningococcal diseaseantibiotic resistancepublic healthvaccine |
| spellingShingle | Yezli S Yassin Y Mushi A Bukhari M Banasser T Khan A Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance Infection and Drug Resistance mass gatherings meningococcal disease antibiotic resistance public health vaccine |
| title | Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance |
| title_full | Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance |
| title_fullStr | Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance |
| title_full_unstemmed | Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance |
| title_short | Carriage of Neisseria meningitidis Among Umrah Pilgrims: Circulating Serogroups and Antibiotic Resistance |
| title_sort | carriage of neisseria meningitidis among umrah pilgrims circulating serogroups and antibiotic resistance |
| topic | mass gatherings meningococcal disease antibiotic resistance public health vaccine |
| url | https://www.dovepress.com/carriage-of-neisseria-meningitidis-among-umrah-pilgrims-circulating-se-peer-reviewed-fulltext-article-IDR |
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