Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study

Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study

Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we investigated the effects of low-molecular-weight fucoidan (oligo-FO) on renal fibrosis under in vitro and in vivo diabetic conditions, and its molecular mechanisms. Advanced glycation product (AGE)-stimulated ra...

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Bibliographic Details
Main Authors: Wen-Chun Yu, Ren-Yeong Huang, Tz-Chong Chou
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
fucoidan
renal fibrosis
diabetes
transforming growth factor-β
Sirt-1
glucagon-like peptide-1 receptor
Online Access:https://www.mdpi.com/2072-6643/12/10/3068

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