Inflammatory myofibroblastic tumor of the larynx
Background/Aim. Inflammatory myofibroblastic tumor (IMT) of the larynx is a rare borderline lesion composed of myofibroblastic and inflammatory cells. Case report. We presented a case of 77-year-old male with hoarseness for about three months. Laryngoscopy showed a polypoid tumor originated from the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2008-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500810779M.pdf |
| _version_ | 1818288884252934144 |
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| author | Mijović Žaklina Mihailović Dragan Kostov Miloš |
| author_facet | Mijović Žaklina Mihailović Dragan Kostov Miloš |
| author_sort | Mijović Žaklina |
| collection | DOAJ |
| description | Background/Aim. Inflammatory myofibroblastic tumor (IMT) of the larynx is a rare borderline lesion composed of myofibroblastic and inflammatory cells. Case report. We presented a case of 77-year-old male with hoarseness for about three months. Laryngoscopy showed a polypoid tumor originated from the anterior commissure with glottic projection. Grossly, the tumor was 22 × 15 mm, whitish, oval nodus with firm consistency. Histologically, the lesion was composed of spindled to stellate cells arranged in a fascicular to storiform pattern and inflammatory cells: lymphocytes, histiocytes, plasma cells and neutrophils. The stroma was fibromyxoid and collagenous. Immunohistochemically, tumor cells showed strong positivity for actin and vimentin and negativity for cytokeratin, CD34, S100 and desmin. The proliferation (Ki67) was less than 10%. Conclusion. Inflammatory myofibroblastic tumor may be mistaken as a malignancy and the differential diagnosis can be difficult without immunohistochemistry. It is critical to recognize this uncommon entity to avoid unnecessary aggressive treatment. |
| first_indexed | 2024-12-13T02:03:28Z |
| format | Article |
| id | doaj.art-324c24f93e1241d9bb08b9ea78b2e316 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-13T02:03:28Z |
| publishDate | 2008-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-324c24f93e1241d9bb08b9ea78b2e3162022-12-22T00:03:13ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502008-01-01651077978210.2298/VSP0810779MInflammatory myofibroblastic tumor of the larynxMijović ŽaklinaMihailović DraganKostov MilošBackground/Aim. Inflammatory myofibroblastic tumor (IMT) of the larynx is a rare borderline lesion composed of myofibroblastic and inflammatory cells. Case report. We presented a case of 77-year-old male with hoarseness for about three months. Laryngoscopy showed a polypoid tumor originated from the anterior commissure with glottic projection. Grossly, the tumor was 22 × 15 mm, whitish, oval nodus with firm consistency. Histologically, the lesion was composed of spindled to stellate cells arranged in a fascicular to storiform pattern and inflammatory cells: lymphocytes, histiocytes, plasma cells and neutrophils. The stroma was fibromyxoid and collagenous. Immunohistochemically, tumor cells showed strong positivity for actin and vimentin and negativity for cytokeratin, CD34, S100 and desmin. The proliferation (Ki67) was less than 10%. Conclusion. Inflammatory myofibroblastic tumor may be mistaken as a malignancy and the differential diagnosis can be difficult without immunohistochemistry. It is critical to recognize this uncommon entity to avoid unnecessary aggressive treatment.http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500810779M.pdflaryngeal neoplasmsneoplasms muscle tissueinflammationimmunohistochemistryotorhinolaryngologic surgical procedures |
| spellingShingle | Mijović Žaklina Mihailović Dragan Kostov Miloš Inflammatory myofibroblastic tumor of the larynx Vojnosanitetski Pregled laryngeal neoplasms neoplasms muscle tissue inflammation immunohistochemistry otorhinolaryngologic surgical procedures |
| title | Inflammatory myofibroblastic tumor of the larynx |
| title_full | Inflammatory myofibroblastic tumor of the larynx |
| title_fullStr | Inflammatory myofibroblastic tumor of the larynx |
| title_full_unstemmed | Inflammatory myofibroblastic tumor of the larynx |
| title_short | Inflammatory myofibroblastic tumor of the larynx |
| title_sort | inflammatory myofibroblastic tumor of the larynx |
| topic | laryngeal neoplasms neoplasms muscle tissue inflammation immunohistochemistry otorhinolaryngologic surgical procedures |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500810779M.pdf |
| work_keys_str_mv | AT mijoviczaklina inflammatorymyofibroblastictumorofthelarynx AT mihailovicdragan inflammatorymyofibroblastictumorofthelarynx AT kostovmilos inflammatorymyofibroblastictumorofthelarynx |