Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient
Abstract Background Cutaneous leishmaniasis (CL) is one of the common tropical protozoal diseases caused by various Leishmania species, and transmitted by the sand-fly vectors, Phlebotomus and Lutzomyia species. Herein, we report for the first time a case of CL that presented as large eczematous pla...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2014-08-01
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| Series: | Parasites & Vectors |
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| Online Access: | https://doi.org/10.1186/1756-3305-7-401 |
| _version_ | 1797811671142498304 |
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| author | Hamida Al-Dwibe Aisha Gashout Abdu-Maged Morogum Said El-Zubi Ahmad Amro |
| author_facet | Hamida Al-Dwibe Aisha Gashout Abdu-Maged Morogum Said El-Zubi Ahmad Amro |
| author_sort | Hamida Al-Dwibe |
| collection | DOAJ |
| description | Abstract Background Cutaneous leishmaniasis (CL) is one of the common tropical protozoal diseases caused by various Leishmania species, and transmitted by the sand-fly vectors, Phlebotomus and Lutzomyia species. Herein, we report for the first time a case of CL that presented as large eczematous plaques occurring on the dorsi of both feet in a Libyan drug addicted, alcoholic patient with HIV infection. Findings A 34 year-old HIV-positive, alcoholic, drug addicted Libyan male presented to us with a history of a non-itchy skin lesions on the dorsi of both feet of 5-weeks duration. Systemic and topical antibiotics were given without improvement. Diagnosis of this patient was confirmed by observation of Leishmania amastigote bodies in stained slit-skin smear skin biopsy. After parenteral administration of sodium stiboglyconate (Pentostam) (20 mg/kg/day) for 28 days the lesions did not show any marked improvement. Concurrently, combination therapy of oral rifampicin (600 mg/day) and isoniazide (300 mg/day) was given for 8 weeks. Complete healing of lesions was achieved after this treatment and skin-slit smears turned negative. Conclusions Localized cutaneous leishmaniasis should be remembered in deferential diagnosis of unresponsive contact dermatitis especially for HIV-positive patients in CL endemic areas. This patient was not responding to Pentostam therapy, which is not very common in Libya. Interestingly, combination of oral rifampicin (600 mg/day) and isoniazide (300 mg/day) can be a successful alternative therapy. |
| first_indexed | 2024-03-13T07:27:09Z |
| format | Article |
| id | doaj.art-324ccdefcd7e40bc896f7c79043759b7 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-13T07:27:09Z |
| publishDate | 2014-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-324ccdefcd7e40bc896f7c79043759b72023-06-04T11:19:15ZengBMCParasites & Vectors1756-33052014-08-01711310.1186/1756-3305-7-401Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patientHamida Al-Dwibe0Aisha Gashout1Abdu-Maged Morogum2Said El-Zubi3Ahmad Amro4Faculty of Medicine, Dermatology Department, University of TripoliFaculty of Medical Technology-Pathology Department, University of TripoliFaculty of Medicine, Dermatology Department, University of TripoliFaculty of Medicine, Dermatology Department, University of TripoliFaculty of Pharmacy, Alquds UniversityAbstract Background Cutaneous leishmaniasis (CL) is one of the common tropical protozoal diseases caused by various Leishmania species, and transmitted by the sand-fly vectors, Phlebotomus and Lutzomyia species. Herein, we report for the first time a case of CL that presented as large eczematous plaques occurring on the dorsi of both feet in a Libyan drug addicted, alcoholic patient with HIV infection. Findings A 34 year-old HIV-positive, alcoholic, drug addicted Libyan male presented to us with a history of a non-itchy skin lesions on the dorsi of both feet of 5-weeks duration. Systemic and topical antibiotics were given without improvement. Diagnosis of this patient was confirmed by observation of Leishmania amastigote bodies in stained slit-skin smear skin biopsy. After parenteral administration of sodium stiboglyconate (Pentostam) (20 mg/kg/day) for 28 days the lesions did not show any marked improvement. Concurrently, combination therapy of oral rifampicin (600 mg/day) and isoniazide (300 mg/day) was given for 8 weeks. Complete healing of lesions was achieved after this treatment and skin-slit smears turned negative. Conclusions Localized cutaneous leishmaniasis should be remembered in deferential diagnosis of unresponsive contact dermatitis especially for HIV-positive patients in CL endemic areas. This patient was not responding to Pentostam therapy, which is not very common in Libya. Interestingly, combination of oral rifampicin (600 mg/day) and isoniazide (300 mg/day) can be a successful alternative therapy.https://doi.org/10.1186/1756-3305-7-401Cutaneous leishmaniasisContact dermatitisHIVSodium stiboglyconate (Pentostam)Libya |
| spellingShingle | Hamida Al-Dwibe Aisha Gashout Abdu-Maged Morogum Said El-Zubi Ahmad Amro Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient Parasites & Vectors Cutaneous leishmaniasis Contact dermatitis HIV Sodium stiboglyconate (Pentostam) Libya |
| title | Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient |
| title_full | Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient |
| title_fullStr | Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient |
| title_full_unstemmed | Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient |
| title_short | Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient |
| title_sort | contact dermatitis like cutaneous leishmaniasis in a libyan hiv patient |
| topic | Cutaneous leishmaniasis Contact dermatitis HIV Sodium stiboglyconate (Pentostam) Libya |
| url | https://doi.org/10.1186/1756-3305-7-401 |
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