Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants

Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants

CRISPR/Cas enables a targeted modification of DNA sequences. Despite their ease and efficient use, one limitation is the potential occurrence of associated off-target effects. This systematic review aims to answer the following research question: Which factors affect the occurrence of off-target eff...

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Bibliographic Details
Main Authors: Dominik Modrzejewski, Frank Hartung, Heike Lehnert, Thorben Sprink, Christian Kohl, Jens Keilwagen, Ralf Wilhelm
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Plant Science
Subjects:
genome editing
unintended effects
off-target mutation
systematic review and meta-analysis
systematic literature search
evidence synthesis
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2020.574959/full

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