Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice
Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived fro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/6/1169 |
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| author | Rossella Di Raimo Davide Mizzoni Massimo Spada Vincenza Dolo Stefano Fais Mariantonia Logozzi |
| author_facet | Rossella Di Raimo Davide Mizzoni Massimo Spada Vincenza Dolo Stefano Fais Mariantonia Logozzi |
| author_sort | Rossella Di Raimo |
| collection | DOAJ |
| description | Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex<sup>®</sup>) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), compared with mice left untreated after the period of H<sub>2</sub>O<sub>2</sub> administration and mice that received only water during the experimental period. The results showed that Exocomplex<sup>®</sup> had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex<sup>®</sup> to the H<sub>2</sub>O<sub>2</sub>-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care. |
| first_indexed | 2024-03-11T02:49:29Z |
| format | Article |
| id | doaj.art-324efacec2764d0ba747c1c204df65dd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T02:49:29Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-324efacec2764d0ba747c1c204df65dd2023-11-18T09:02:25ZengMDPI AGAntioxidants2076-39212023-05-01126116910.3390/antiox12061169Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated MiceRossella Di Raimo0Davide Mizzoni1Massimo Spada2Vincenza Dolo3Stefano Fais4Mariantonia Logozzi5Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, ItalyDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, ItalyDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, ItalyDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, ItalyDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, ItalyPlant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex<sup>®</sup>) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), compared with mice left untreated after the period of H<sub>2</sub>O<sub>2</sub> administration and mice that received only water during the experimental period. The results showed that Exocomplex<sup>®</sup> had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex<sup>®</sup> to the H<sub>2</sub>O<sub>2</sub>-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care.https://www.mdpi.com/2076-3921/12/6/1169plant-derived exosomesantioxidantsanti-aginganti-stressnatural bioactiveshealth |
| spellingShingle | Rossella Di Raimo Davide Mizzoni Massimo Spada Vincenza Dolo Stefano Fais Mariantonia Logozzi Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice Antioxidants plant-derived exosomes antioxidants anti-aging anti-stress natural bioactives health |
| title | Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice |
| title_full | Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice |
| title_fullStr | Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice |
| title_full_unstemmed | Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice |
| title_short | Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H<sub>2</sub>O<sub>2</sub>-Treated Mice |
| title_sort | oral treatment with plant derived exosomes restores redox balance in h sub 2 sub o sub 2 sub treated mice |
| topic | plant-derived exosomes antioxidants anti-aging anti-stress natural bioactives health |
| url | https://www.mdpi.com/2076-3921/12/6/1169 |
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