Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment
Background:. Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native ty...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2019-01-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002047 |
| _version_ | 1818162064867196928 |
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| author | Alisha R. Oropallo, MD, FACS |
| author_facet | Alisha R. Oropallo, MD, FACS |
| author_sort | Alisha R. Oropallo, MD, FACS |
| collection | DOAJ |
| description | Background:. Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native type I collagen matrix with the antimicrobial polyhexamethylene biguanide (PCMP) in the management of bioburden and treatment of chronic, nonhealing wounds over 12 weeks.
Methods:. A prospective case series of PCMP enrolled adults ≥18 years old with a nonhealing wound. At week 0, the wound was prepared by sharp or mechanical debridement. Patients received standard wound care plus PCMP applications at week 0 and then weekly up to week 12 at the investigator’s discretion. Dressings were applied over PCMP to fix it in place. At each visit, wounds were assessed for the extent of healing and signs of wound infection.
Results:. Of the 41 wounds studied, 44% were pressure ulcers, 22% were surgical wounds, 12% were venous ulcers, 10% were diabetic ulcers, and 12% were another type. The median (interquartile range) baseline wound area was 7.2 (14.9) cm2, and the mean wound duration was 103 weeks. Of the 41 wounds, 73% demonstrated a reduction in wound area at 12 weeks, and 37% achieved complete wound closure, with a mean time of 6.7 weeks to complete closure.
Conclusion:. PCMP treatment appeared to positively impact the course of wound healing in a variety of complex, chronic wounds that were unresponsive to prior treatment. |
| first_indexed | 2024-12-11T16:27:44Z |
| format | Article |
| id | doaj.art-324f44dabea6410fa665ec47d258454c |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-12-11T16:27:44Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-324f44dabea6410fa665ec47d258454c2022-12-22T00:58:41ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742019-01-0171e204710.1097/GOX.0000000000002047201901000-00019Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound TreatmentAlisha R. Oropallo, MD, FACS0From the *Department of Surgery, Northwell Health, Lake Success, N.Y.Background:. Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native type I collagen matrix with the antimicrobial polyhexamethylene biguanide (PCMP) in the management of bioburden and treatment of chronic, nonhealing wounds over 12 weeks. Methods:. A prospective case series of PCMP enrolled adults ≥18 years old with a nonhealing wound. At week 0, the wound was prepared by sharp or mechanical debridement. Patients received standard wound care plus PCMP applications at week 0 and then weekly up to week 12 at the investigator’s discretion. Dressings were applied over PCMP to fix it in place. At each visit, wounds were assessed for the extent of healing and signs of wound infection. Results:. Of the 41 wounds studied, 44% were pressure ulcers, 22% were surgical wounds, 12% were venous ulcers, 10% were diabetic ulcers, and 12% were another type. The median (interquartile range) baseline wound area was 7.2 (14.9) cm2, and the mean wound duration was 103 weeks. Of the 41 wounds, 73% demonstrated a reduction in wound area at 12 weeks, and 37% achieved complete wound closure, with a mean time of 6.7 weeks to complete closure. Conclusion:. PCMP treatment appeared to positively impact the course of wound healing in a variety of complex, chronic wounds that were unresponsive to prior treatment.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002047 |
| spellingShingle | Alisha R. Oropallo, MD, FACS Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment Plastic and Reconstructive Surgery, Global Open |
| title | Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment |
| title_full | Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment |
| title_fullStr | Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment |
| title_full_unstemmed | Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment |
| title_short | Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment |
| title_sort | use of native type i collagen matrix plus polyhexamethylene biguanide for chronic wound treatment |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002047 |
| work_keys_str_mv | AT alisharoropallomdfacs useofnativetypeicollagenmatrixpluspolyhexamethylenebiguanideforchronicwoundtreatment |