Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identif...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-021-00405-z |
| _version_ | 1831714128014606336 |
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| author | Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones |
| author_facet | Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones |
| author_sort | Bernadette C. Baker |
| collection | DOAJ |
| description | Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth. |
| first_indexed | 2024-12-20T23:53:48Z |
| format | Article |
| id | doaj.art-324f8ca743a641bbb7a14311b4b8d9c3 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-20T23:53:48Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-324f8ca743a641bbb7a14311b4b8d9c32022-12-21T19:22:46ZengBMCBiology of Sex Differences2042-64102021-11-0112112010.1186/s13293-021-00405-zSexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restrictionBernadette C. Baker0Sylvia Lui1Isabel Lorne2Alexander E. P. Heazell3Karen Forbes4Rebecca L. Jones5Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, University of ManchesterDivision of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, University of ManchesterDivision of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, University of ManchesterDivision of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, University of ManchesterDiscovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of LeedsDivision of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, University of ManchesterHighlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth.https://doi.org/10.1186/s13293-021-00405-zmiRNAPlacentaPregnancySerumBiomarkerPlacental dysfunction |
| spellingShingle | Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction Biology of Sex Differences miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction |
| title | Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_full | Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_fullStr | Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_full_unstemmed | Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_short | Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_sort | sexually dimorphic patterns in maternal circulating micrornas in pregnancies complicated by fetal growth restriction |
| topic | miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction |
| url | https://doi.org/10.1186/s13293-021-00405-z |
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