Approaches to pandemic prevention – the chromatin vaccine
Developing effective vaccines against viral infections have significant impacts on development, prosperity and well-being of human populations. Thus, successful vaccines such as smallpox and polio vaccines, have promoted global societal well-being. In contrast, ineffective vaccines may fuel argument...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324084/full |
| _version_ | 1797400641963819008 |
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| author | Jielin Zhang Philip Askenase Rudolf Jaenisch Clyde S. Crumpacker |
| author_facet | Jielin Zhang Philip Askenase Rudolf Jaenisch Clyde S. Crumpacker |
| author_sort | Jielin Zhang |
| collection | DOAJ |
| description | Developing effective vaccines against viral infections have significant impacts on development, prosperity and well-being of human populations. Thus, successful vaccines such as smallpox and polio vaccines, have promoted global societal well-being. In contrast, ineffective vaccines may fuel arguments that retard scientific progress. We aim to stimulate a multilevel discussion on how to develop effective vaccines against recent and future pandemics by focusing on acquired immunodeficiency syndrome (AIDS), coronavirus disease (COVID) and other viral infections. We appeal to harnessing recent achievements in this field specifically towards a cure for current pandemics and prevention of the next pandemics. Among these, we propose to apply the HIV DNA in chromatin format – an end product of aborted HIV integration in episomal forms, i.e., the chromatin vaccines (cVacc), to elicit the epigenetic silencing and memory that prevent viral replication and infection. |
| first_indexed | 2024-03-09T01:58:29Z |
| format | Article |
| id | doaj.art-32518098acd649799718a66acb48bf30 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T01:58:29Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-32518098acd649799718a66acb48bf302023-12-08T10:45:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13240841324084Approaches to pandemic prevention – the chromatin vaccineJielin Zhang0Philip Askenase1Rudolf Jaenisch2Clyde S. Crumpacker3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesAllergy & Clinical Immunology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Biology, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDeveloping effective vaccines against viral infections have significant impacts on development, prosperity and well-being of human populations. Thus, successful vaccines such as smallpox and polio vaccines, have promoted global societal well-being. In contrast, ineffective vaccines may fuel arguments that retard scientific progress. We aim to stimulate a multilevel discussion on how to develop effective vaccines against recent and future pandemics by focusing on acquired immunodeficiency syndrome (AIDS), coronavirus disease (COVID) and other viral infections. We appeal to harnessing recent achievements in this field specifically towards a cure for current pandemics and prevention of the next pandemics. Among these, we propose to apply the HIV DNA in chromatin format – an end product of aborted HIV integration in episomal forms, i.e., the chromatin vaccines (cVacc), to elicit the epigenetic silencing and memory that prevent viral replication and infection.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324084/fullvaccine efficacyvaccine breakthroughviral pathogenicitychromatin vaccine (cVacc)epigenetic immunity |
| spellingShingle | Jielin Zhang Philip Askenase Rudolf Jaenisch Clyde S. Crumpacker Approaches to pandemic prevention – the chromatin vaccine Frontiers in Immunology vaccine efficacy vaccine breakthrough viral pathogenicity chromatin vaccine (cVacc) epigenetic immunity |
| title | Approaches to pandemic prevention – the chromatin vaccine |
| title_full | Approaches to pandemic prevention – the chromatin vaccine |
| title_fullStr | Approaches to pandemic prevention – the chromatin vaccine |
| title_full_unstemmed | Approaches to pandemic prevention – the chromatin vaccine |
| title_short | Approaches to pandemic prevention – the chromatin vaccine |
| title_sort | approaches to pandemic prevention the chromatin vaccine |
| topic | vaccine efficacy vaccine breakthrough viral pathogenicity chromatin vaccine (cVacc) epigenetic immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324084/full |
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