Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease
Clinical trials for Alzheimer’s disease (AD) face multiple challenges, such as the high screen failure rate and the even allocation of heterogeneous participants. Artificial intelligence (AI), which has become a potent tool of modern science with the expansion in the volume, variety, and velocity of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/2/275 |
| _version_ | 1797478607999729664 |
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| author | Younghoon Seo Hyemin Jang Hyejoo Lee |
| author_facet | Younghoon Seo Hyemin Jang Hyejoo Lee |
| author_sort | Younghoon Seo |
| collection | DOAJ |
| description | Clinical trials for Alzheimer’s disease (AD) face multiple challenges, such as the high screen failure rate and the even allocation of heterogeneous participants. Artificial intelligence (AI), which has become a potent tool of modern science with the expansion in the volume, variety, and velocity of biological data, offers promising potential to address these issues in AD clinical trials. In this review, we introduce the current status of AD clinical trials and the topic of machine learning. Then, a comprehensive review is focused on the potential applications of AI in the steps of AD clinical trials, including the prediction of protein and MRI AD biomarkers in the prescreening process during eligibility assessment and the likelihood stratification of AD subjects into rapid and slow progressors in randomization. Finally, this review provides challenges, developments, and the future outlook on the integration of AI into AD clinical trials. |
| first_indexed | 2024-03-09T21:34:07Z |
| format | Article |
| id | doaj.art-3251eb6194f04e0db921d8b6986eaeff |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T21:34:07Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3251eb6194f04e0db921d8b6986eaeff2023-11-23T20:46:47ZengMDPI AGLife2075-17292022-02-0112227510.3390/life12020275Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s DiseaseYounghoon Seo0Hyemin Jang1Hyejoo Lee2Samsung Alzheimer Research Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, KoreaSamsung Alzheimer Research Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, KoreaSamsung Alzheimer Research Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, KoreaClinical trials for Alzheimer’s disease (AD) face multiple challenges, such as the high screen failure rate and the even allocation of heterogeneous participants. Artificial intelligence (AI), which has become a potent tool of modern science with the expansion in the volume, variety, and velocity of biological data, offers promising potential to address these issues in AD clinical trials. In this review, we introduce the current status of AD clinical trials and the topic of machine learning. Then, a comprehensive review is focused on the potential applications of AI in the steps of AD clinical trials, including the prediction of protein and MRI AD biomarkers in the prescreening process during eligibility assessment and the likelihood stratification of AD subjects into rapid and slow progressors in randomization. Finally, this review provides challenges, developments, and the future outlook on the integration of AI into AD clinical trials.https://www.mdpi.com/2075-1729/12/2/275Alzheimer’s diseaseartificial intelligenceclinical trialseligibility assessmentrandomization |
| spellingShingle | Younghoon Seo Hyemin Jang Hyejoo Lee Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease Life Alzheimer’s disease artificial intelligence clinical trials eligibility assessment randomization |
| title | Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease |
| title_full | Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease |
| title_fullStr | Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease |
| title_full_unstemmed | Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease |
| title_short | Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer’s Disease |
| title_sort | potential applications of artificial intelligence in clinical trials for alzheimer s disease |
| topic | Alzheimer’s disease artificial intelligence clinical trials eligibility assessment randomization |
| url | https://www.mdpi.com/2075-1729/12/2/275 |
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