A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling processes and are potential therapeutics for the treat...

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Bibliographic Details
Main Authors: Tom van der Wel, Freek J. Janssen, Marc P. Baggelaar, Hui Deng, Hans den Dulk, Herman S. Overkleeft, Mario van der Stelt
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Lipid Research
Subjects:
2-arachidonoylglycerol
cannabinoids
endocannabinoid
enzymology
lipids
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355735

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http://www.sciencedirect.com/science/article/pii/S0022227520355735

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