Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions
OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2021-08-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100302&tlng=en |
| _version_ | 1811229629387636736 |
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| author | Tatiana Carvalho de Souza Bonetti Flavia Roche Moreira Latini Adriana Lukow Invitti Marcelo Cunio Machado Fonseca Fulvio Alexandre Scorza Maira Garcia Saldanha Fernanda T. Bellucco Natalia B.S. Bacarov Michel M. Soane Manoel João Batista Castelo Girão |
| author_facet | Tatiana Carvalho de Souza Bonetti Flavia Roche Moreira Latini Adriana Lukow Invitti Marcelo Cunio Machado Fonseca Fulvio Alexandre Scorza Maira Garcia Saldanha Fernanda T. Bellucco Natalia B.S. Bacarov Michel M. Soane Manoel João Batista Castelo Girão |
| author_sort | Tatiana Carvalho de Souza Bonetti |
| collection | DOAJ |
| description | OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies. METHODS: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms. RESULTS: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms. CONCLUSIONS: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered. |
| first_indexed | 2024-04-12T10:16:40Z |
| format | Article |
| id | doaj.art-3254e7ca54104a0d8c0f0fd445ab7358 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:40Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-3254e7ca54104a0d8c0f0fd445ab73582022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222021-08-017610.6061/clinics/2021/e2818Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questionsTatiana Carvalho de Souza Bonettihttps://orcid.org/0000-0002-5193-700XFlavia Roche Moreira Latinihttps://orcid.org/0000-0001-6649-7855Adriana Lukow Invittihttps://orcid.org/0000-0003-2392-2887Marcelo Cunio Machado Fonsecahttps://orcid.org/0000-0003-0803-3715Fulvio Alexandre Scorzahttps://orcid.org/0000-0002-0694-8674Maira Garcia Saldanhahttps://orcid.org/0000-0002-6324-2029Fernanda T. Belluccohttps://orcid.org/0000-0002-4198-2667Natalia B.S. Bacarovhttps://orcid.org/0000-0001-8393-6565Michel M. Soanehttps://orcid.org/0000-0002-3187-1736Manoel João Batista Castelo Girãohttps://orcid.org/0000-0002-3379-5802OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies. METHODS: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms. RESULTS: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms. CONCLUSIONS: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100302&tlng=enSARS-CoV-2COVID-19AntibodiesDisease Severity |
| spellingShingle | Tatiana Carvalho de Souza Bonetti Flavia Roche Moreira Latini Adriana Lukow Invitti Marcelo Cunio Machado Fonseca Fulvio Alexandre Scorza Maira Garcia Saldanha Fernanda T. Bellucco Natalia B.S. Bacarov Michel M. Soane Manoel João Batista Castelo Girão Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions Clinics SARS-CoV-2 COVID-19 Antibodies Disease Severity |
| title | Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
| title_full | Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
| title_fullStr | Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
| title_full_unstemmed | Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
| title_short | Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
| title_sort | antibody indexes in covid 19 convalescent plasma donors unanswered questions |
| topic | SARS-CoV-2 COVID-19 Antibodies Disease Severity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100302&tlng=en |
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