A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts

A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts

Mechanotransduction is elicited in cells upon the perception of physical forces transmitted via the extracellular matrix in their surroundings and results in signaling events that impact cellular functions. This physiological process is a prerequisite for maintaining the integrity of diarthrodial jo...

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Bibliographic Details
Main Authors: Tomasz Janczi, Florian Meier, Yuliya Fehrl, Raimund W. Kinne, Beate Böhm, Harald Burkhardt
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
mechanotransduction
ADAM15
SIRT1
long non-coding RNA
HOTAIR
TRPV4
Online Access:https://www.mdpi.com/2073-4409/10/10/2705

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