miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice
Highlights Osteocytic microRNA21 (miR21) removal in OtmiR21Δ mice alters cytokine production and bone mass by modulating osteoclast and osteoblast differentiation and activity. Only female, but not male, OtmiR21Δ mice exhibit higher lean body mass and soleus and gastrocnemius muscle weight compared...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Biology of Sex Differences |
| Online Access: | https://doi.org/10.1186/s13293-022-00465-9 |
| _version_ | 1811253627676786688 |
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| author | Alyson L. Essex Padmini Deosthale Joshua R. Huot Hannah M. Davis Nicholas Momeni Andrea Bonetto Lilian I. Plotkin |
| author_facet | Alyson L. Essex Padmini Deosthale Joshua R. Huot Hannah M. Davis Nicholas Momeni Andrea Bonetto Lilian I. Plotkin |
| author_sort | Alyson L. Essex |
| collection | DOAJ |
| description | Highlights Osteocytic microRNA21 (miR21) removal in OtmiR21Δ mice alters cytokine production and bone mass by modulating osteoclast and osteoblast differentiation and activity. Only female, but not male, OtmiR21Δ mice exhibit higher lean body mass and soleus and gastrocnemius muscle weight compared to miR21fl/fl littermates. Sex-dependent consequences of osteocytic miR21 deletion on skeletal muscle were also found at protein and gene expression level. We conclude that osteocyte-derived miR21 influences skeletal muscle size, but not strength, in female but not male mice; whereas, intracellular signaling alterations resulting from loss of miR21 seem to alter protein dynamics in a sex-dimorphic fashion. |
| first_indexed | 2024-04-12T16:53:35Z |
| format | Article |
| id | doaj.art-32579b5541ce4b178601001da8bd2692 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-12T16:53:35Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-32579b5541ce4b178601001da8bd26922022-12-22T03:24:18ZengBMCBiology of Sex Differences2042-64102022-10-0113111210.1186/s13293-022-00465-9miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in miceAlyson L. Essex0Padmini Deosthale1Joshua R. Huot2Hannah M. Davis3Nicholas Momeni4Andrea Bonetto5Lilian I. Plotkin6Department of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of MedicineHighlights Osteocytic microRNA21 (miR21) removal in OtmiR21Δ mice alters cytokine production and bone mass by modulating osteoclast and osteoblast differentiation and activity. Only female, but not male, OtmiR21Δ mice exhibit higher lean body mass and soleus and gastrocnemius muscle weight compared to miR21fl/fl littermates. Sex-dependent consequences of osteocytic miR21 deletion on skeletal muscle were also found at protein and gene expression level. We conclude that osteocyte-derived miR21 influences skeletal muscle size, but not strength, in female but not male mice; whereas, intracellular signaling alterations resulting from loss of miR21 seem to alter protein dynamics in a sex-dimorphic fashion.https://doi.org/10.1186/s13293-022-00465-9 |
| spellingShingle | Alyson L. Essex Padmini Deosthale Joshua R. Huot Hannah M. Davis Nicholas Momeni Andrea Bonetto Lilian I. Plotkin miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice Biology of Sex Differences |
| title | miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice |
| title_full | miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice |
| title_fullStr | miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice |
| title_full_unstemmed | miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice |
| title_short | miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice |
| title_sort | mir21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex dimorphic manner in mice |
| url | https://doi.org/10.1186/s13293-022-00465-9 |
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