In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

ABSTRACT A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethy...

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Bibliographic Details
Main Authors:	Wendy Leticia Guerra-Ponce, Sandra Leticia Gracia-Vásquez, Patricia González-Barranco, Ivonne Antonieta Camacho-Mora, Yolanda Araceli Gracia-Vásquez, Elizabeth Orozco-Beltrán, Linda Anne Felton
Format:	Article
Language:	English
Published:	Universidade de São Paulo
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Ibuprofen/study Ibuprofen/sustained release tablets Ibuprofen/formulation/carbopol Ibuprofen/formulation/hydroxypropyl methylcellulose Ibuprofen/formulations/ethyl cellulose Ibuprofen/formulations/release kinetics.
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400751&lng=en&tlng=en

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