Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding

Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding

Activation of T cells by agonistic peptide-MHC can be inhibited by antagonistic ones. However, the exact mechanism remains elusive. We used Jurkat cells expressing two different TCRs and tested whether stimulation of the endogenous TCR by agonistic anti-Vβ8 antibodies can be modulated by ligand-bind...

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Bibliographic Details
Main Authors: Omid Sascha Yousefi, Matias Ruggieri, Vincent Idstein, Kai Uwe von Prillwitz, Laurenz A. Herr, Julia Chalupsky, Maja Köhn, Wilfried Weber, Jens Timmer, Wolfgang W. A. Schamel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
antagonism
signaling
TCR
T cell activation
modeling
synthetic biology
Online Access:https://www.mdpi.com/1422-0067/22/9/4920

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