1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.
The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3883702?pdf=render |
| _version_ | 1818822772283932672 |
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| author | Estela Castilla-Ortega Leticia Escuredo Ainhoa Bilbao Carmen Pedraza Laura Orio Guillermo Estivill-Torrús Luis J Santín Fernando Rodríguez de Fonseca Francisco Javier Pavón |
| author_facet | Estela Castilla-Ortega Leticia Escuredo Ainhoa Bilbao Carmen Pedraza Laura Orio Guillermo Estivill-Torrús Luis J Santín Fernando Rodríguez de Fonseca Francisco Javier Pavón |
| author_sort | Estela Castilla-Ortega |
| collection | DOAJ |
| description | The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression. |
| first_indexed | 2024-12-18T23:29:24Z |
| format | Article |
| id | doaj.art-325a52dfedb24dd7bc1b1ff62487dc93 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T23:29:24Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-325a52dfedb24dd7bc1b1ff62487dc932022-12-21T20:47:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8534810.1371/journal.pone.00853481-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.Estela Castilla-OrtegaLeticia EscuredoAinhoa BilbaoCarmen PedrazaLaura OrioGuillermo Estivill-TorrúsLuis J SantínFernando Rodríguez de FonsecaFrancisco Javier PavónThe role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.http://europepmc.org/articles/PMC3883702?pdf=render |
| spellingShingle | Estela Castilla-Ortega Leticia Escuredo Ainhoa Bilbao Carmen Pedraza Laura Orio Guillermo Estivill-Torrús Luis J Santín Fernando Rodríguez de Fonseca Francisco Javier Pavón 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS ONE |
| title | 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. |
| title_full | 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. |
| title_fullStr | 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. |
| title_full_unstemmed | 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. |
| title_short | 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. |
| title_sort | 1 oleoyl lysophosphatidic acid a new mediator of emotional behavior in rats |
| url | http://europepmc.org/articles/PMC3883702?pdf=render |
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