Relationship of serum leptin level with irritable bowel syndrome
Background and Objective: Stress has been known as an important causative factor in irritable bowel syndrome. Various studies have indicated the relationship between serum leptin levels and stress levels. This study was undertaken to investigate the relationship between serum leptin levels with irri...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2009-05-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-342&slc_lang=en&sid=1 |
| _version_ | 1818365619417907200 |
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| author | Shahryar Semnani (MD) Gholamreza Roshandel (MD) Abbasali Keshtkar(PhD) Laily Najafi (MD) Taghi Amiriani (MD) Mehran Farajollahi (MD) Abdolvahab Moradi (PhD) Hamidreza Joshaghani (PhD) Amirhossein Noohi (MD) Nafiseh Abdolahi (MD) |
| author_facet | Shahryar Semnani (MD) Gholamreza Roshandel (MD) Abbasali Keshtkar(PhD) Laily Najafi (MD) Taghi Amiriani (MD) Mehran Farajollahi (MD) Abdolvahab Moradi (PhD) Hamidreza Joshaghani (PhD) Amirhossein Noohi (MD) Nafiseh Abdolahi (MD) |
| author_sort | Shahryar Semnani (MD) |
| collection | DOAJ |
| description | Background and Objective: Stress has been known as an important causative factor in irritable bowel syndrome. Various studies have indicated the relationship between serum leptin levels and stress levels. This study was undertaken to investigate the relationship between serum leptin levels with irritable bowel syndrome. Materials and Methods: In This case-control study, eighty irritable bowel syndrome patients and 80 controls were recruited. All participants were asked to fill in a questionnaire included demographic information and medical history as well as a stress questionnaire. Serum leptin level was measured by ELISA method. Chi-square, student t-test, pearson correlation and logistic regression were used for investigating the relationships between variables. Results: Participants in irritable bowel syndrome group had significantly higher stress levels than controls (p<0.05). In the other hand, Serum leptin levels were significantly lower in irritable bowel syndrome group than the other one (p<0.05). Multivariate logistic regression analysis showed that after adjustment of stress level and body mass index, serum leptin level was still significantly lower in irritable bowel syndrome group (Odds ratio=0.9 CI95%:0.85-0.94). Conclusion: The present study indicated that there is a relationship between leptin and irritable bowel syndrome and serum leptin level is significantly lower in irritable bowel syndrome group than controls. This relationship is independent of other variables such as stress levels, BMI. |
| first_indexed | 2024-12-13T22:23:09Z |
| format | Article |
| id | doaj.art-325ae5bc665a4b46947d21157036d5d8 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-13T22:23:09Z |
| publishDate | 2009-05-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-325ae5bc665a4b46947d21157036d5d82022-12-21T23:29:17ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802009-05-011112632Relationship of serum leptin level with irritable bowel syndromeShahryar Semnani (MD)0Gholamreza Roshandel (MD)1Abbasali Keshtkar(PhD)2Laily Najafi (MD)3Taghi Amiriani (MD)4Mehran Farajollahi (MD)5Abdolvahab Moradi (PhD)6Hamidreza Joshaghani (PhD)7Amirhossein Noohi (MD)8Nafiseh Abdolahi (MD)9 Background and Objective: Stress has been known as an important causative factor in irritable bowel syndrome. Various studies have indicated the relationship between serum leptin levels and stress levels. This study was undertaken to investigate the relationship between serum leptin levels with irritable bowel syndrome. Materials and Methods: In This case-control study, eighty irritable bowel syndrome patients and 80 controls were recruited. All participants were asked to fill in a questionnaire included demographic information and medical history as well as a stress questionnaire. Serum leptin level was measured by ELISA method. Chi-square, student t-test, pearson correlation and logistic regression were used for investigating the relationships between variables. Results: Participants in irritable bowel syndrome group had significantly higher stress levels than controls (p<0.05). In the other hand, Serum leptin levels were significantly lower in irritable bowel syndrome group than the other one (p<0.05). Multivariate logistic regression analysis showed that after adjustment of stress level and body mass index, serum leptin level was still significantly lower in irritable bowel syndrome group (Odds ratio=0.9 CI95%:0.85-0.94). Conclusion: The present study indicated that there is a relationship between leptin and irritable bowel syndrome and serum leptin level is significantly lower in irritable bowel syndrome group than controls. This relationship is independent of other variables such as stress levels, BMI.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-342&slc_lang=en&sid=1Irritable Bowel SyndromeLeptinStress |
| spellingShingle | Shahryar Semnani (MD) Gholamreza Roshandel (MD) Abbasali Keshtkar(PhD) Laily Najafi (MD) Taghi Amiriani (MD) Mehran Farajollahi (MD) Abdolvahab Moradi (PhD) Hamidreza Joshaghani (PhD) Amirhossein Noohi (MD) Nafiseh Abdolahi (MD) Relationship of serum leptin level with irritable bowel syndrome مجله دانشگاه علوم پزشکی گرگان Irritable Bowel Syndrome Leptin Stress |
| title | Relationship of serum leptin level with irritable bowel syndrome |
| title_full | Relationship of serum leptin level with irritable bowel syndrome |
| title_fullStr | Relationship of serum leptin level with irritable bowel syndrome |
| title_full_unstemmed | Relationship of serum leptin level with irritable bowel syndrome |
| title_short | Relationship of serum leptin level with irritable bowel syndrome |
| title_sort | relationship of serum leptin level with irritable bowel syndrome |
| topic | Irritable Bowel Syndrome Leptin Stress |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-342&slc_lang=en&sid=1 |
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