Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi]
Background: During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of the pandemic Influenza A (H1N1) Influenza in cancer patients during the 2009 influenza season. Methods: Twelve centers participated in a multicenter retrospective observational study of can...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
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F1000 Research Ltd
2014-09-01
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| Online Access: | http://f1000research.com/articles/3-221/v1 |
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| author | Maria Cecilia Dignani Patricia Costantini Claudia Salgueira Rosana Jordán Graciela Guerrini Alejandra Valledor Fabián Herrera Andrea Nenna Claudia Mora Inés Roccia-Rossi Daniel Stecher Edith Carbone Ana Laborde Ernesto Efron Javier Altclas Aníbal Calmaggi José Cozzi |
| author_facet | Maria Cecilia Dignani Patricia Costantini Claudia Salgueira Rosana Jordán Graciela Guerrini Alejandra Valledor Fabián Herrera Andrea Nenna Claudia Mora Inés Roccia-Rossi Daniel Stecher Edith Carbone Ana Laborde Ernesto Efron Javier Altclas Aníbal Calmaggi José Cozzi |
| author_sort | Maria Cecilia Dignani |
| collection | DOAJ |
| description | Background: During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of the pandemic Influenza A (H1N1) Influenza in cancer patients during the 2009 influenza season. Methods: Twelve centers participated in a multicenter retrospective observational study of cancer patients with confirmed infection with the 2009 H1N1 Influenza A virus (influenza-like illness or pneumonia plus positive PCR for the 2009 H1N1 Influenza A virus in respiratory secretions). Clinical data were obtained by retrospective chart review and analyzed. Results: From May to August 2009, data of 65 patients were collected. Median age was 51 years, 57 % of the patients were female. Most patients (47) had onco-hematological cancers and 18 had solid tumors. Cancer treatment mainly consisted of chemotherapy (46), or stem cell transplantation (SCT) (16). Only 19 of 64 patients had received the 2009 seasonal Influenza vaccine. Clinical presentation included pneumonia (43) and upper respiratory tract infection (22). Forty five of 58 ambulatory patients were admitted. Mechanical ventilation was required in 12 patients (18%). Treatment included oseltamivir monotherapy or in combination with amantadine for a median of 7 days. The global 30-day mortality rate was 18%. All 12 deaths were among the non-vaccinated patients. No deaths were observed among the 19 vaccinated patients. Oxygen saturation <96% at presentation was a predictor of mortality (OR 19.5; 95%CI: 2.28 to 165.9). Conclusions: In our cancer patient population, the pandemic 2009 Influenza A (H1N1) virus was associated with high incidence of pneumonia (66%), and 30-day mortality (18.5%). Saturation <96% was significantly associated with death. No deaths were observed among vaccinated patients. |
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| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T12:47:59Z |
| publishDate | 2014-09-01 |
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| spelling | doaj.art-325d803a27a44c2bbe93ce25913abff42022-12-21T20:20:41ZengF1000 Research LtdF1000Research2046-14022014-09-01310.12688/f1000research.5251.15598Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi]Maria Cecilia Dignani0Patricia Costantini1Claudia Salgueira2Rosana Jordán3Graciela Guerrini4Alejandra Valledor5Fabián Herrera6Andrea Nenna7Claudia Mora8Inés Roccia-Rossi9Daniel Stecher10Edith Carbone11Ana Laborde12Ernesto Efron13Javier Altclas14Aníbal Calmaggi15José Cozzi16Commission of Infections in Immunocompromised Patients, Argentinean Society of Infectious Diseases (SADI), Buenos Aires, 1085, ArgentinaInfectious Diseases, Instituto de Oncología Angel H. Roffo, University of Buenos Aires, Buenos Aires, 1417, ArgentinaInfectious Diseases, Sanatorio Anchorena 1425 and Sanatorio Trinidad Mitre, Buenos Aires, 1430, ArgentinaInfectious Diseases, Hospital Británico, Buenos Aires, 1280, ArgentinaInfectious Diseases, Hospital Rossi, Buenos Aires, 1900, ArgentinaInfectious Diseases, Hospital Italiano, Buenos Aires, 1181, ArgentinaInfectious Diseases, CEMIC, Buenos Aires, 1425, ArgentinaInfectious Diseases, Hospital Municipal de Oncología “Marie Curie”, Buenos Aires, 1405, ArgentinaInfectious Diseases, FLENI, Buenos Aires, 1428, ArgentinaHospital San Martín, Buenos Aires, 1900, ArgentinaInfectious Diseases, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, 1120, ArgentinaInfectious Diseases, Hospital Aeronáutico Central, Buenos Aires, 1437, ArgentinaInfectious Diseases, FUNDALEU, Buenos Aires, 1114, ArgentinaArgentinean Society of Infectious Diseases (SADI), Buenos Aires, 1085, ArgentinaArgentinean Society of Infectious Diseases (SADI), Buenos Aires, 1085, ArgentinaInfectious Diseases, Hospital Rossi, Buenos Aires, 1900, ArgentinaBone Marrow Transplant, CETRAMOR, Rosario, Pcia. Sta Fé, 2000, ArgentinaBackground: During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of the pandemic Influenza A (H1N1) Influenza in cancer patients during the 2009 influenza season. Methods: Twelve centers participated in a multicenter retrospective observational study of cancer patients with confirmed infection with the 2009 H1N1 Influenza A virus (influenza-like illness or pneumonia plus positive PCR for the 2009 H1N1 Influenza A virus in respiratory secretions). Clinical data were obtained by retrospective chart review and analyzed. Results: From May to August 2009, data of 65 patients were collected. Median age was 51 years, 57 % of the patients were female. Most patients (47) had onco-hematological cancers and 18 had solid tumors. Cancer treatment mainly consisted of chemotherapy (46), or stem cell transplantation (SCT) (16). Only 19 of 64 patients had received the 2009 seasonal Influenza vaccine. Clinical presentation included pneumonia (43) and upper respiratory tract infection (22). Forty five of 58 ambulatory patients were admitted. Mechanical ventilation was required in 12 patients (18%). Treatment included oseltamivir monotherapy or in combination with amantadine for a median of 7 days. The global 30-day mortality rate was 18%. All 12 deaths were among the non-vaccinated patients. No deaths were observed among the 19 vaccinated patients. Oxygen saturation <96% at presentation was a predictor of mortality (OR 19.5; 95%CI: 2.28 to 165.9). Conclusions: In our cancer patient population, the pandemic 2009 Influenza A (H1N1) virus was associated with high incidence of pneumonia (66%), and 30-day mortality (18.5%). Saturation <96% was significantly associated with death. No deaths were observed among vaccinated patients.http://f1000research.com/articles/3-221/v1Clinical ImmunologyNosocomial & Healthcare-Associated InfectionsViral Infections (without HIV) |
| spellingShingle | Maria Cecilia Dignani Patricia Costantini Claudia Salgueira Rosana Jordán Graciela Guerrini Alejandra Valledor Fabián Herrera Andrea Nenna Claudia Mora Inés Roccia-Rossi Daniel Stecher Edith Carbone Ana Laborde Ernesto Efron Javier Altclas Aníbal Calmaggi José Cozzi Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] F1000Research Clinical Immunology Nosocomial & Healthcare-Associated Infections Viral Infections (without HIV) |
| title | Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] |
| title_full | Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] |
| title_fullStr | Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] |
| title_full_unstemmed | Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] |
| title_short | Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study. [v1; ref status: indexed, http://f1000r.es/4bi] |
| title_sort | pandemic 2009 influenza a h1n1 virus infection in cancer and hematopoietic stem cell transplant recipients a multicenter observational study v1 ref status indexed http f1000r es 4bi |
| topic | Clinical Immunology Nosocomial & Healthcare-Associated Infections Viral Infections (without HIV) |
| url | http://f1000research.com/articles/3-221/v1 |
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