Mast cell function modulating IgE-mediated allergy
Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators, such as histami...
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| Format: | Article |
| Language: | English |
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Elsevier
1999-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015314829 |
| _version_ | 1818616472439619584 |
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| author | Ruby Pawankar |
| author_facet | Ruby Pawankar |
| author_sort | Ruby Pawankar |
| collection | DOAJ |
| description | Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators, such as histamine, leukotrienes and prostaglandins. In contrast, T lymphocytes, basophils and eosinophils are thought to be responsible for inducing the late phase response. However, whether the mast cell can be simplistically assigned a role in the immediate phase allergic response and whether mast cells are necessary for the ongoing allergic response, including the development of hyperresponsiveness, remains to be completely studied. In the present article, the author will discuss the integrated roles of mast cells in IgE-mediated allergic inflammation, with specific emphasis on the roles of mast cell-derived cytokines in the late phase allergic response and chronic allergic inflammation. |
| first_indexed | 2024-12-16T16:50:21Z |
| format | Article |
| id | doaj.art-325f7faaaee74259b4b250e61ca235fe |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-16T16:50:21Z |
| publishDate | 1999-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-325f7faaaee74259b4b250e61ca235fe2022-12-21T22:24:03ZengElsevierAllergology International1323-89301999-01-0148317118210.1046/j.1440-1592.1999.00138.xMast cell function modulating IgE-mediated allergyRuby PawankarAllergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators, such as histamine, leukotrienes and prostaglandins. In contrast, T lymphocytes, basophils and eosinophils are thought to be responsible for inducing the late phase response. However, whether the mast cell can be simplistically assigned a role in the immediate phase allergic response and whether mast cells are necessary for the ongoing allergic response, including the development of hyperresponsiveness, remains to be completely studied. In the present article, the author will discuss the integrated roles of mast cells in IgE-mediated allergic inflammation, with specific emphasis on the roles of mast cell-derived cytokines in the late phase allergic response and chronic allergic inflammation.http://www.sciencedirect.com/science/article/pii/S1323893015314829allergyFceRIlocal IgE synthesismast cell |
| spellingShingle | Ruby Pawankar Mast cell function modulating IgE-mediated allergy Allergology International allergy FceRI local IgE synthesis mast cell |
| title | Mast cell function modulating IgE-mediated allergy |
| title_full | Mast cell function modulating IgE-mediated allergy |
| title_fullStr | Mast cell function modulating IgE-mediated allergy |
| title_full_unstemmed | Mast cell function modulating IgE-mediated allergy |
| title_short | Mast cell function modulating IgE-mediated allergy |
| title_sort | mast cell function modulating ige mediated allergy |
| topic | allergy FceRI local IgE synthesis mast cell |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015314829 |
| work_keys_str_mv | AT rubypawankar mastcellfunctionmodulatingigemediatedallergy |