Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug
Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/14/1/1 |
| _version_ | 1798003541557641216 |
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| author | Javier A. García-Vilas Beatriz Martínez-Poveda Ana R. Quesada Miguel Ángel Medina |
| author_facet | Javier A. García-Vilas Beatriz Martínez-Poveda Ana R. Quesada Miguel Ángel Medina |
| author_sort | Javier A. García-Vilas |
| collection | DOAJ |
| description | Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies. |
| first_indexed | 2024-04-11T12:10:33Z |
| format | Article |
| id | doaj.art-325fcdb0fb734a8ea787d70306746a6c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:10:33Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-325fcdb0fb734a8ea787d70306746a6c2022-12-22T04:24:38ZengMDPI AGMarine Drugs1660-33972015-12-01141110.3390/md14010001md14010001Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine DrugJavier A. García-Vilas0Beatriz Martínez-Poveda1Ana R. Quesada2Miguel Ángel Medina3Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, SpainDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, SpainDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, SpainDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, SpainOrganisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.http://www.mdpi.com/1660-3397/14/1/1(+)-aeroplysinin-1spongesmarine drugsinflammationangiogenesiscancer |
| spellingShingle | Javier A. García-Vilas Beatriz Martínez-Poveda Ana R. Quesada Miguel Ángel Medina Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug Marine Drugs (+)-aeroplysinin-1 sponges marine drugs inflammation angiogenesis cancer |
| title | Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug |
| title_full | Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug |
| title_fullStr | Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug |
| title_full_unstemmed | Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug |
| title_short | Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug |
| title_sort | aeroplysinin 1 a sponge derived multi targeted bioactive marine drug |
| topic | (+)-aeroplysinin-1 sponges marine drugs inflammation angiogenesis cancer |
| url | http://www.mdpi.com/1660-3397/14/1/1 |
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