Morphological characterization of the AlphaA- and AlphaB-crystallin double knockout mouse lens

Morphological characterization of the AlphaA- and AlphaB-crystallin double knockout mouse lens

<p>Abstract</p> <p>Background</p> <p>One approach to resolving some of the <it>in vivo </it>functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystalli...

Full description

Bibliographic Details
Main Authors:	Brady James P, Takemoto Larry, Boyle Daniel L, Wawrousek Eric F
Format:	Article
Language:	English
Published:	BMC 2003-01-01
Series:	BMC Ophthalmology
Online Access:	http://www.biomedcentral.com/1471-2415/3/3

Similar Items

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function.
by: Laganowsky, A, et al.
Published: (2010)

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
by: Meehan, S, et al.
Published: (2007)

Association of the chaperone alphaB-crystallin with titin in heart muscle.
by: Bullard, B, et al.
Published: (2004)

Interaction of C-terminal truncated human alphaA-crystallins with target proteins.
by: Anbarasu Kumarasamy, et al.
Published: (2008-09-01)

Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity.
by: Ecroyd, H, et al.
Published: (2007)

R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable.
by: Treweek, T, et al.
Published: (2005)

Suppression of neuroinflammation by the dopamine receptor D2 via alphaB-crystallin
by: Zhou Jiawei
Published: (2012-02-01)

Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation.
by: Aquilina, J, et al.
Published: (2005)

Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation
by: Aquilina, J, et al.
Published: (2005)

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
by: Rekas, A, et al.
Published: (2004)

Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure.
by: Aquilina, J, et al.
Published: (2004)

Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure.
by: Aquilina, J, et al.
Published: (2004)

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin.
by: Aquilina, J, et al.
Published: (2003)

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin
by: Aquilina, J, et al.
Published: (2003)

BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity.
by: Akinori Hishiya, et al.
Published: (2011-03-01)

Interactive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassembly.
by: Joy G Ghosh, et al.
Published: (2007-06-01)

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy
by: Lin Douglas I, et al.
Published: (2007-01-01)

Site-directed mutations in the C-terminal extension of human alphaB-crystallin affect chaperone function and block amyloid fibril formation.
by: Teresa M Treweek, et al.
Published: (2007-10-01)

Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.
by: Cheryl Frankfater, et al.
Published: (2020-01-01)

Correction: Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.
by: PLOS ONE Staff
Published: (2020-01-01)

The characterization of human [gamma]D-crystallin mutants and their differential interactions with the lens chaperone [alpha]B-crystallin
by: Moreau, Kate L. (Kate Lauren)
Published: (2011)

Binding of Alpha-Crystallin to Cortical and Nuclear Lens Lipid Membranes Derived from a Single Lens
by: Raju Timsina, et al.
Published: (2022-09-01)

Modulation of the Structure and Stability of Novel Camel Lens Alpha-Crystallin by pH and Thermal Stress
by: Ajamaluddin Malik, et al.
Published: (2022-04-01)

Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse
by: Rudradip Pattanayak, et al.
Published: (2022-06-01)

In vitro interactions of the small heat shock protein chaperone human [alpha]B-crystallin with its physiological substrates in the lens [gamma]-crystallins
by: Acosta-Sampson, Ligia I
Published: (2011)

Recombination and identification of human alpha B-crystallin
by: Rui Wang, et al.
Published: (2018-12-01)

Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract
by: Preston Hazen, et al.
Published: (2024-02-01)

Association of Alpha-Crystallin with Fiber Cell Plasma Membrane of the Eye Lens Accompanied by Light Scattering and Cataract Formation
by: Raju Timsina, et al.
Published: (2021-06-01)

Role of the Alpha-B-Crystallin Protein in Cardiomyopathic Disease
by: Andres Thorkelsson, et al.
Published: (2024-02-01)

The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study.
by: Carver, J, et al.
Published: (2002)

Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model
by: Filippo Naso, et al.
Published: (2023-06-01)

A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.
by: Diggle, C, et al.
Published: (2017)

A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.
by: Christine P Diggle, et al.
Published: (2017-01-01)

Elasticity Changes in the Crystalline Lens during Oxidative Damage and the Antioxidant Effect of Alpha-Lipoic Acid Measured by Optical Coherence Elastography
by: Hongqiu Zhang, et al.
Published: (2021-06-01)

Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity
by: Rekas, A, et al.
Published: (2004)

The sufi dictionary of Al-Qashani's mystic terminology : an alphabeical reference of Sufi's terms /
by: Al-Kayyali, Asim Ibrahim , author 409405
Published: (2011)

Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis
by: Emiko Mizoguchi, et al.
Published: (2021-11-01)

Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse.
by: Atherton, H, et al.
Published: (2009)

Alpha B-Crystallin in Muscle Disease Prevention: The Role of Physical Activity
by: Ivan Dimauro, et al.
Published: (2022-02-01)

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
by: Behnam Rashidieh, et al.
Published: (2023-01-01)