Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Abstract Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A alters brain development or is associated...

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Bibliographic Details
Main Authors: Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson, Michael J. Gandal
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Genome Biology
Subjects:
Schizophrenia
Psychosis
Neuroimaging
Genetics
Gene expression
Complement
Online Access:https://doi.org/10.1186/s13059-023-02878-0

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