The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase
Over the years, we have noticed in our clinical practice that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL are more symptomatic than those with higher levels. The aim of this research is to investigate changes in both parathyroid hormone (PTH) and alkaline phosphatase (ALP) at dif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2828 |
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| author | Hussein Abdullah Rajab |
| author_facet | Hussein Abdullah Rajab |
| author_sort | Hussein Abdullah Rajab |
| collection | DOAJ |
| description | Over the years, we have noticed in our clinical practice that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL are more symptomatic than those with higher levels. The aim of this research is to investigate changes in both parathyroid hormone (PTH) and alkaline phosphatase (ALP) at different vitamin D levels to determine if lower vitamin D levels are associated with more severe changes in PTH and ALP, which may explain the presence and severity of symptoms at those lower 25OHD levels. We looked for correlations between 25OHD level, PTH, and ALP in 1311 samples between 2015 and 2019 at our endocrine clinic to determine if vitamin D level correlates with changes in PTH and ALP. We further categorized vitamin D deficiency levels into three categories based on the severity of the reported symptoms. As expected, there were inverse but significant correlations between 25OHD, PTH, and ALP. The lower the 25OHD, the higher the PTH and ALP levels. When 25OHD was below 10 ng/mL, PTH was increased in 65% of the samples and ALP was elevated in 21% of the samples; however, PTH and ALP were normal in 70% and 87%, respectively, of patients with 25OHD levels between 15 < 20 ng/mL. The results support our clinical observations since most of the patients with 25OHD greater than 15 ng/mL had normal PTH and ALP, which may explain the lack of symptoms in these patients. |
| first_indexed | 2024-03-09T18:23:14Z |
| format | Article |
| id | doaj.art-3265f702045e41cf8f6514d52d68f371 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T18:23:14Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-3265f702045e41cf8f6514d52d68f3712023-11-24T08:04:56ZengMDPI AGDiagnostics2075-44182022-11-011211282810.3390/diagnostics12112828The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline PhosphataseHussein Abdullah Rajab0Najran University Hospital, Medical College, Najran University, Najran 66255, Saudi ArabiaOver the years, we have noticed in our clinical practice that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL are more symptomatic than those with higher levels. The aim of this research is to investigate changes in both parathyroid hormone (PTH) and alkaline phosphatase (ALP) at different vitamin D levels to determine if lower vitamin D levels are associated with more severe changes in PTH and ALP, which may explain the presence and severity of symptoms at those lower 25OHD levels. We looked for correlations between 25OHD level, PTH, and ALP in 1311 samples between 2015 and 2019 at our endocrine clinic to determine if vitamin D level correlates with changes in PTH and ALP. We further categorized vitamin D deficiency levels into three categories based on the severity of the reported symptoms. As expected, there were inverse but significant correlations between 25OHD, PTH, and ALP. The lower the 25OHD, the higher the PTH and ALP levels. When 25OHD was below 10 ng/mL, PTH was increased in 65% of the samples and ALP was elevated in 21% of the samples; however, PTH and ALP were normal in 70% and 87%, respectively, of patients with 25OHD levels between 15 < 20 ng/mL. The results support our clinical observations since most of the patients with 25OHD greater than 15 ng/mL had normal PTH and ALP, which may explain the lack of symptoms in these patients.https://www.mdpi.com/2075-4418/12/11/282825-hydroxyvitamin D (25OHD)parathyroid hormone (PTH)alkaline phosphatase (ALP) |
| spellingShingle | Hussein Abdullah Rajab The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase Diagnostics 25-hydroxyvitamin D (25OHD) parathyroid hormone (PTH) alkaline phosphatase (ALP) |
| title | The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase |
| title_full | The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase |
| title_fullStr | The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase |
| title_full_unstemmed | The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase |
| title_short | The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase |
| title_sort | effect of vitamin d level on parathyroid hormone and alkaline phosphatase |
| topic | 25-hydroxyvitamin D (25OHD) parathyroid hormone (PTH) alkaline phosphatase (ALP) |
| url | https://www.mdpi.com/2075-4418/12/11/2828 |
| work_keys_str_mv | AT husseinabdullahrajab theeffectofvitamindlevelonparathyroidhormoneandalkalinephosphatase AT husseinabdullahrajab effectofvitamindlevelonparathyroidhormoneandalkalinephosphatase |