Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

In neurodegenerative diseases like AD, tau forms neurofibrillary tangles, composed of tau protein. In the AD brain, activated caspases cleave tau at the 421th Asp, generating a caspase-cleaved form of tau, TauC3. Although TauC3 is known to assemble rapidly into filaments in vitro, a role of TauC3 in...

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Bibliographic Details
Main Authors: YoungDoo Kim, Hyunwoo Choi, WonJae Lee, Hyejin Park, Tae-In Kam, Se-hoon Hong, Jihoon Nah, Sunmin Jung, Bora Shin, Huikyong Lee, Tae-Yong Choi, Hyosun Choo, Kyung-Keun Kim, Se-Young Choi, Rakez Kayed, Yong-Keun Jung
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Neurobiology of Disease
Subjects:
Caspase-cleaved tau
Tauopathy
Alzheimer's disease
Tau oligomers
AD mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115301078

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