Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients
Abstract Background Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. The benefit of Fibroscan in assessing the risk of developing liver cancer that was evaluated in this work was not fully demonstrated. The aim of thi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43055-020-00258-3 |
| _version_ | 1818991473173987328 |
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| author | Ahmed Elhosieny Ebrahim Mona Ahmed Helmy Shehata Sabry Abou-saif Manal fathy Hamisa Sherief Abd-Elsalam Mohamed Yousef |
| author_facet | Ahmed Elhosieny Ebrahim Mona Ahmed Helmy Shehata Sabry Abou-saif Manal fathy Hamisa Sherief Abd-Elsalam Mohamed Yousef |
| author_sort | Ahmed Elhosieny Ebrahim |
| collection | DOAJ |
| description | Abstract Background Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. The benefit of Fibroscan in assessing the risk of developing liver cancer that was evaluated in this work was not fully demonstrated. The aim of this work was to study the role and clinical significance of Fibroscan for early detection of liver cancer in hepatitis C patients with cirrhosis. Results As regards binary logistic regression for predictors of HCC, it was found that Child C, AST, Fibroscan, and AFP were predictors for developing HCC. Liver stiffness values were significantly high in all groups, and the specific cutoff value for hepatocellular carcinoma detection was above 24 kPa in hepatitis C virus patients. Therefore, liver stiffness of more than 24 kPa can be considered as an independent risk factor for the development of liver cancer in HCV patients. Conclusion Liver stiffness of more than 24 kPa was an independent risk factor for developing new liver cancer in HCV patients. |
| first_indexed | 2024-12-20T20:10:49Z |
| format | Article |
| id | doaj.art-32672d3defbd46c690dea770bca54bfd |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-20T20:10:49Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-32672d3defbd46c690dea770bca54bfd2022-12-21T19:27:48ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-07-015111610.1186/s43055-020-00258-3Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patientsAhmed Elhosieny Ebrahim0Mona Ahmed Helmy Shehata1Sabry Abou-saif2Manal fathy Hamisa3Sherief Abd-Elsalam4Mohamed Yousef5Kafr-Elsheikh General HospitalDepartment of Tropical Medicine, Faculty of Medicine, Tanta University Hospital, Tanta UniversityDepartment of Tropical Medicine, Faculty of Medicine, Tanta University Hospital, Tanta UniversityDiagnostic Radiology Department, Tanta UniversityDepartment of Tropical Medicine, Faculty of Medicine, Tanta University Hospital, Tanta UniversityDepartment of Tropical Medicine, Faculty of Medicine, Tanta University Hospital, Tanta UniversityAbstract Background Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. The benefit of Fibroscan in assessing the risk of developing liver cancer that was evaluated in this work was not fully demonstrated. The aim of this work was to study the role and clinical significance of Fibroscan for early detection of liver cancer in hepatitis C patients with cirrhosis. Results As regards binary logistic regression for predictors of HCC, it was found that Child C, AST, Fibroscan, and AFP were predictors for developing HCC. Liver stiffness values were significantly high in all groups, and the specific cutoff value for hepatocellular carcinoma detection was above 24 kPa in hepatitis C virus patients. Therefore, liver stiffness of more than 24 kPa can be considered as an independent risk factor for the development of liver cancer in HCV patients. Conclusion Liver stiffness of more than 24 kPa was an independent risk factor for developing new liver cancer in HCV patients.http://link.springer.com/article/10.1186/s43055-020-00258-3HCCFibroscanLiver diseaseCirrhosisPredictionPrevalence |
| spellingShingle | Ahmed Elhosieny Ebrahim Mona Ahmed Helmy Shehata Sabry Abou-saif Manal fathy Hamisa Sherief Abd-Elsalam Mohamed Yousef Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients The Egyptian Journal of Radiology and Nuclear Medicine HCC Fibroscan Liver disease Cirrhosis Prediction Prevalence |
| title | Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients |
| title_full | Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients |
| title_fullStr | Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients |
| title_full_unstemmed | Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients |
| title_short | Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients |
| title_sort | role of fibroscan for early detection of hepatocellular carcinoma hcc in hepatitis c cirrhotic patients |
| topic | HCC Fibroscan Liver disease Cirrhosis Prediction Prevalence |
| url | http://link.springer.com/article/10.1186/s43055-020-00258-3 |
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