Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients
Abstract Background Preoperative sarcopenia is an important risk factor for postoperative complications in patients with gastric cancer. However, the relationship between muscle quality and postoperative complications in patients with gastric cancer is inadequately studied. Therefore, we investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12452 |
| _version_ | 1797870297229033472 |
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| author | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji |
| author_facet | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji |
| author_sort | Ryota Matsui |
| collection | DOAJ |
| description | Abstract Background Preoperative sarcopenia is an important risk factor for postoperative complications in patients with gastric cancer. However, the relationship between muscle quality and postoperative complications in patients with gastric cancer is inadequately studied. Therefore, we investigated the impact of preoperative muscle quality on severe postoperative complications after radical gastrectomy. Methods A total of 840 patients who underwent radical gastrectomy for p‐stages I–III primary gastric cancer between April 2008 and June 2018 with preoperative computed tomography (CT) scans and body composition analysis were included. We measured intramuscular adipose tissue content (IMAC) as an indicator of muscle quality. A higher IMAC signified a poorer quality. All statistical analyses were performed with EZR, and a P‐value < 0.05 was considered statistically significant. Results The low‐IMAC and high‐IMAC groups had 422 (50.2%) and 418 (49.8%) patients, respectively. The latter were older (P < 0.001), had higher body mass index (BMI) (P < 0.001), and higher rates of chronic kidney disease (CKD) (P = 0.002) and diabetes (P < 0.001). They had lower skeletal muscle indexes (SMI) (P = 0.011) and higher visceral fat areas (VFA) (P < 0.001). They also experienced more intraoperative blood loss (P < 0.001) and greater complications (P = 0.016). Multivariate analysis showed that high‐IMAC was an independent risk factor for severe complications (odds ratio: 2.260, 95% confidence interval: 1.220‐4.190, P = 0.010). Conclusions Poor preoperative muscle quality is an independent risk factor for severe postoperative complications after radical gastrectomy in patients with gastric cancer. |
| first_indexed | 2024-04-10T00:25:04Z |
| format | Article |
| id | doaj.art-32673c90c98d49a2afc07a951ef6f094 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-10T00:25:04Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-32673c90c98d49a2afc07a951ef6f0942023-03-15T10:05:47ZengWileyAnnals of Gastroenterological Surgery2475-03282021-07-015451051810.1002/ags3.12452Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patientsRyota Matsui0Noriyuki Inaki1Toshikatsu Tsuji2Department of Gastroenterological Surgery Ishikawa Prefectural Central Hospital Kanazawa JapanDepartment of Gastroenterological Surgery Ishikawa Prefectural Central Hospital Kanazawa JapanDepartment of Gastroenterological Surgery Ishikawa Prefectural Central Hospital Kanazawa JapanAbstract Background Preoperative sarcopenia is an important risk factor for postoperative complications in patients with gastric cancer. However, the relationship between muscle quality and postoperative complications in patients with gastric cancer is inadequately studied. Therefore, we investigated the impact of preoperative muscle quality on severe postoperative complications after radical gastrectomy. Methods A total of 840 patients who underwent radical gastrectomy for p‐stages I–III primary gastric cancer between April 2008 and June 2018 with preoperative computed tomography (CT) scans and body composition analysis were included. We measured intramuscular adipose tissue content (IMAC) as an indicator of muscle quality. A higher IMAC signified a poorer quality. All statistical analyses were performed with EZR, and a P‐value < 0.05 was considered statistically significant. Results The low‐IMAC and high‐IMAC groups had 422 (50.2%) and 418 (49.8%) patients, respectively. The latter were older (P < 0.001), had higher body mass index (BMI) (P < 0.001), and higher rates of chronic kidney disease (CKD) (P = 0.002) and diabetes (P < 0.001). They had lower skeletal muscle indexes (SMI) (P = 0.011) and higher visceral fat areas (VFA) (P < 0.001). They also experienced more intraoperative blood loss (P < 0.001) and greater complications (P = 0.016). Multivariate analysis showed that high‐IMAC was an independent risk factor for severe complications (odds ratio: 2.260, 95% confidence interval: 1.220‐4.190, P = 0.010). Conclusions Poor preoperative muscle quality is an independent risk factor for severe postoperative complications after radical gastrectomy in patients with gastric cancer.https://doi.org/10.1002/ags3.12452gastric cancerintramuscular adipose tissue contentmuscle qualitypostoperative severe complication |
| spellingShingle | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients Annals of Gastroenterological Surgery gastric cancer intramuscular adipose tissue content muscle quality postoperative severe complication |
| title | Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| title_full | Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| title_fullStr | Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| title_full_unstemmed | Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| title_short | Impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| title_sort | impact of preoperative muscle quality on postoperative severe complications after radical gastrectomy for gastric cancer patients |
| topic | gastric cancer intramuscular adipose tissue content muscle quality postoperative severe complication |
| url | https://doi.org/10.1002/ags3.12452 |
| work_keys_str_mv | AT ryotamatsui impactofpreoperativemusclequalityonpostoperativeseverecomplicationsafterradicalgastrectomyforgastriccancerpatients AT noriyukiinaki impactofpreoperativemusclequalityonpostoperativeseverecomplicationsafterradicalgastrectomyforgastriccancerpatients AT toshikatsutsuji impactofpreoperativemusclequalityonpostoperativeseverecomplicationsafterradicalgastrectomyforgastriccancerpatients |