Metabolic approach to heart failure: The role of metabolic modulators
Heart failure (HF) is a systemic and multiorgan syndrome with metabolic failure as fundamental mechanism. As a consequence of its impaired metabolism, other processes are activated in the failing heart, further exacerbating the progression of HF. Metabolic agents are a relatively new class of drugs...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-09-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110260815000290 |
| _version_ | 1798043613840539648 |
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| author | Giuseppe M.C. Rosano Cristiana Vitale Ilaria Spoletini |
| author_facet | Giuseppe M.C. Rosano Cristiana Vitale Ilaria Spoletini |
| author_sort | Giuseppe M.C. Rosano |
| collection | DOAJ |
| description | Heart failure (HF) is a systemic and multiorgan syndrome with metabolic failure as fundamental mechanism. As a consequence of its impaired metabolism, other processes are activated in the failing heart, further exacerbating the progression of HF.
Metabolic agents are a relatively new class of drugs that act through optimisation of cardiac substrate metabolism. Among the metabolic modulators, Trimetazidine (TMZ) and perhexiline are the only two agents with proven anti-ischaemic effect currently available. However, due to its major side effects, perhexiline is not yet approved in the US or Europe.
Clinical trials have demonstrated that the adjunct of TMZ to optimal medical therapy improves symptoms and prognosis of HF without exerting negative hemodynamic effects. Due to its anti-ischaemic/anti-anginal effect and excellent tolerability, the modulation of cardiac metabolism with TMZ represents a promising approach for the treatment of patients with HF. |
| first_indexed | 2024-04-11T22:51:32Z |
| format | Article |
| id | doaj.art-3267f6ec5f9f44d5b836bc5f87cd9e7d |
| institution | Directory Open Access Journal |
| issn | 1110-2608 |
| language | English |
| last_indexed | 2024-04-11T22:51:32Z |
| publishDate | 2015-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-3267f6ec5f9f44d5b836bc5f87cd9e7d2022-12-22T03:58:33ZengSpringerOpenThe Egyptian Heart Journal1110-26082015-09-0167317718110.1016/j.ehj.2015.03.004Metabolic approach to heart failure: The role of metabolic modulatorsGiuseppe M.C. Rosano0Cristiana Vitale1Ilaria Spoletini2Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, ItalyDepartment of Medical Sciences, IRCCS San Raffaele Pisana, Rome, ItalyDepartment of Medical Sciences, IRCCS San Raffaele Pisana, Rome, ItalyHeart failure (HF) is a systemic and multiorgan syndrome with metabolic failure as fundamental mechanism. As a consequence of its impaired metabolism, other processes are activated in the failing heart, further exacerbating the progression of HF. Metabolic agents are a relatively new class of drugs that act through optimisation of cardiac substrate metabolism. Among the metabolic modulators, Trimetazidine (TMZ) and perhexiline are the only two agents with proven anti-ischaemic effect currently available. However, due to its major side effects, perhexiline is not yet approved in the US or Europe. Clinical trials have demonstrated that the adjunct of TMZ to optimal medical therapy improves symptoms and prognosis of HF without exerting negative hemodynamic effects. Due to its anti-ischaemic/anti-anginal effect and excellent tolerability, the modulation of cardiac metabolism with TMZ represents a promising approach for the treatment of patients with HF.http://www.sciencedirect.com/science/article/pii/S1110260815000290Heart failureMetabolismTrimetazidineTreatment |
| spellingShingle | Giuseppe M.C. Rosano Cristiana Vitale Ilaria Spoletini Metabolic approach to heart failure: The role of metabolic modulators The Egyptian Heart Journal Heart failure Metabolism Trimetazidine Treatment |
| title | Metabolic approach to heart failure: The role of metabolic modulators |
| title_full | Metabolic approach to heart failure: The role of metabolic modulators |
| title_fullStr | Metabolic approach to heart failure: The role of metabolic modulators |
| title_full_unstemmed | Metabolic approach to heart failure: The role of metabolic modulators |
| title_short | Metabolic approach to heart failure: The role of metabolic modulators |
| title_sort | metabolic approach to heart failure the role of metabolic modulators |
| topic | Heart failure Metabolism Trimetazidine Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1110260815000290 |
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