Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy.

Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy.

Previously we have shown that ovariectomised (OVX) female sheep have reduced renal function and elevated blood pressure from 6 months of age following fetal uninephrectomy (uni-x) at 100 days of gestation (term = 150 days). In the current study we examined if in intact female sheep the onset of decl...

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Bibliographic Details
Main Authors: Reetu R Singh, Andrew J Jefferies, Yugeesh R Lankadeva, Paul Lombardo, Michal Schneider-Kolsky, Lucinda Hilliard, Kate M Denton, Karen M Moritz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22879965/pdf/?tool=EBI

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