Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
Abstract Background The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typi...
Main Authors: | Steven C. Eastlack, Shengli Dong, Cristina Ivan, Suresh K. Alahari |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-07-01
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Series: | Molecular Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12943-018-0851-8 |
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