Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis
AbstractTo improve the anti-metastasis effects of honokiol (HNK) on breast cancer, we designed cationic liposomes (Lip) in which HNK was encapsulated into Lip, and its surface was modified with negatively charged polysialic acid (PSA-Lip-HNK) for efficient treatment of breast cancer. PSA-Lip-HNK pos...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2023.2181746 |
| _version_ | 1797260981000208384 |
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| author | Xin Li Shuang Guan Henan Li Dong Li Dan Liu Jing Wang Wenquan Zhu Guihua Xing Liling Yue Defu Cai Qi Zhang |
| author_facet | Xin Li Shuang Guan Henan Li Dong Li Dan Liu Jing Wang Wenquan Zhu Guihua Xing Liling Yue Defu Cai Qi Zhang |
| author_sort | Xin Li |
| collection | DOAJ |
| description | AbstractTo improve the anti-metastasis effects of honokiol (HNK) on breast cancer, we designed cationic liposomes (Lip) in which HNK was encapsulated into Lip, and its surface was modified with negatively charged polysialic acid (PSA-Lip-HNK) for efficient treatment of breast cancer. PSA-Lip-HNK possessed a homogeneous spherical shape and high encapsulation efficiency. In vitro 4T1 cell experiments indicated that PSA-Lip-HNK increased cellular uptake and cytotoxicity via the endocytosis pathway mediated by PSA and selectin receptors. Furthermore, the significant antitumor metastasis impact of PSA-Lip-HNK was confirmed by wound healing and cell migration and invasion. Enhanced in vivo tumor accumulation of the PSA-Lip-HNK was observed in 4T1 tumor-bearing mice by living fluorescence imaging. For in vivo antitumor experiments using 4T1 tumor-bearing mice, PSA-Lip-HNK exhibited a higher tumor growth and metastasis inhibition compared with unmodified liposomes. Therefore, we believe that PSA-Lip-HNK well combined biocompatible PSA nano-delivery and chemotherapy, providing a promising drug delivery approach for metastatic breast cancer therapy. |
| first_indexed | 2024-03-08T23:31:30Z |
| format | Article |
| id | doaj.art-326b76d15a204f84aa291a1e1876364d |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-24T23:33:57Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-326b76d15a204f84aa291a1e1876364d2024-03-15T14:22:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642023-12-0130110.1080/10717544.2023.2181746Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasisXin Li0Shuang Guan1Henan Li2Dong Li3Dan Liu4Jing Wang5Wenquan Zhu6Guihua Xing7Liling Yue8Defu Cai9Qi Zhang10Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaCollege of Pharmacy, Qiqihar Medical University, Qiqihar, P.R. ChinaCollege of Pathology, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaInstitute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, P.R. ChinaAbstractTo improve the anti-metastasis effects of honokiol (HNK) on breast cancer, we designed cationic liposomes (Lip) in which HNK was encapsulated into Lip, and its surface was modified with negatively charged polysialic acid (PSA-Lip-HNK) for efficient treatment of breast cancer. PSA-Lip-HNK possessed a homogeneous spherical shape and high encapsulation efficiency. In vitro 4T1 cell experiments indicated that PSA-Lip-HNK increased cellular uptake and cytotoxicity via the endocytosis pathway mediated by PSA and selectin receptors. Furthermore, the significant antitumor metastasis impact of PSA-Lip-HNK was confirmed by wound healing and cell migration and invasion. Enhanced in vivo tumor accumulation of the PSA-Lip-HNK was observed in 4T1 tumor-bearing mice by living fluorescence imaging. For in vivo antitumor experiments using 4T1 tumor-bearing mice, PSA-Lip-HNK exhibited a higher tumor growth and metastasis inhibition compared with unmodified liposomes. Therefore, we believe that PSA-Lip-HNK well combined biocompatible PSA nano-delivery and chemotherapy, providing a promising drug delivery approach for metastatic breast cancer therapy.https://www.tandfonline.com/doi/10.1080/10717544.2023.2181746Breast cancermetastasishonokiolpolysialic acidliposomes |
| spellingShingle | Xin Li Shuang Guan Henan Li Dong Li Dan Liu Jing Wang Wenquan Zhu Guihua Xing Liling Yue Defu Cai Qi Zhang Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis Drug Delivery Breast cancer metastasis honokiol polysialic acid liposomes |
| title | Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| title_full | Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| title_fullStr | Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| title_full_unstemmed | Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| title_short | Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| title_sort | polysialic acid functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis |
| topic | Breast cancer metastasis honokiol polysialic acid liposomes |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2023.2181746 |
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