Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma

Adoptive transfer of tumor antigen-specific CD8+ T cells can limit tumor progression but is hampered by the T cells’ rapid functional impairment within the tumor microenvironment (TME). This is in part caused by metabolic stress due to lack of oxygen and glucose. Here, we report that fenofibrate tre...

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Bibliographic Details
Main Authors:	Mohadeseh Hasanpourghadi, Arezki Chekaoui, Sophia Kurian, Raj Kurupati, Robert Ambrose, Wynetta Giles-Davis, Amara Saha, Xu Xiaowei, Hildegund C.J. Ertl
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	Molecular Therapy: Oncolytics
Subjects:	melanoma T cell metabolism tumor antigen-specific T cells PDX mouse model PPARα agonist treatment
Online Access:	http://www.sciencedirect.com/science/article/pii/S2372770523000931

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http://www.sciencedirect.com/science/article/pii/S2372770523000931

Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma

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