Expressions and Significances of CRABPII and E-FABP in Non-small Cell Lung Cancer
Background and objective The cellular retinoic acid-binding protein II (CRABPII) and epidermal fatty acid-binding protein (E-FABP) both serving as the transport protein of retinoic acid (RA), through RA signal transduction pathway, commit the cell to opposite fate, apoptosis or survival. The aim of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2013-01-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.03 |
| _version_ | 1831755941664522240 |
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| author | Qian LIU Shifeng WANG Huan XU Shangfu ZHANG |
| author_facet | Qian LIU Shifeng WANG Huan XU Shangfu ZHANG |
| author_sort | Qian LIU |
| collection | DOAJ |
| description | Background and objective The cellular retinoic acid-binding protein II (CRABPII) and epidermal fatty acid-binding protein (E-FABP) both serving as the transport protein of retinoic acid (RA), through RA signal transduction pathway, commit the cell to opposite fate, apoptosis or survival. The aim of this study is to investigate the expression of CRABPII and E-FABP and significance in non-small cell lung cancer (NSCLC) and their lymph node metastases with tissue microarray technique. Methods CRABPII and E-FABP proteins were detected in 54 normal lung tissues, 287 primary NSCLC tissues and 112 lymph node metastatic tissues by SP method of immunohistochemical staining. Results The expression level of CRABPII in the primary lesions was relevant to the gender of NSCLC patients, the metastasis and TNM staging of NSCLC (P<0.05), while the expression level of E-FABP was related to the grading and metastasis of NSCLC (P<0.05). The positive expression rate of E-FABP in NSCLC primary lesion was remarkably higher than that in adjacent normal lung tissues and lymph node metastases, respectively (P<0.05). The expression level of E-FABP had a recognizable advantage over that of CRABPII in NSCLC primary lesions (P<0.05). The differential expressions between CRABPII and E-FABP was correlated with the tumor size, grading, metastasis, TNM staging of NSCLC (P<0.05). The larger the tumor was and the later the TNM staging was, along with cancer metastasis, the more likely the expression of E-FABP would dominate. The expression of CRABPII and difference expression between CRABPII and E-FABP were closely related to the prognosis of NSCLC patients based on Kaplan-Meier survival analysis. Conclusion E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC. CRABPII might have a negative effect in NSCLC progression, and its expression was negatively related to the prognosis of NSCLC patients. |
| first_indexed | 2024-12-22T00:05:18Z |
| format | Article |
| id | doaj.art-326dc77e45954aa08848ac57c6b6c331 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-22T00:05:18Z |
| publishDate | 2013-01-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-326dc77e45954aa08848ac57c6b6c3312022-12-21T18:45:35ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872013-01-01161121910.3779/j.issn.1009-3419.2013.01.03Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung CancerQian LIUShifeng WANGHuan XUShangfu ZHANGBackground and objective The cellular retinoic acid-binding protein II (CRABPII) and epidermal fatty acid-binding protein (E-FABP) both serving as the transport protein of retinoic acid (RA), through RA signal transduction pathway, commit the cell to opposite fate, apoptosis or survival. The aim of this study is to investigate the expression of CRABPII and E-FABP and significance in non-small cell lung cancer (NSCLC) and their lymph node metastases with tissue microarray technique. Methods CRABPII and E-FABP proteins were detected in 54 normal lung tissues, 287 primary NSCLC tissues and 112 lymph node metastatic tissues by SP method of immunohistochemical staining. Results The expression level of CRABPII in the primary lesions was relevant to the gender of NSCLC patients, the metastasis and TNM staging of NSCLC (P<0.05), while the expression level of E-FABP was related to the grading and metastasis of NSCLC (P<0.05). The positive expression rate of E-FABP in NSCLC primary lesion was remarkably higher than that in adjacent normal lung tissues and lymph node metastases, respectively (P<0.05). The expression level of E-FABP had a recognizable advantage over that of CRABPII in NSCLC primary lesions (P<0.05). The differential expressions between CRABPII and E-FABP was correlated with the tumor size, grading, metastasis, TNM staging of NSCLC (P<0.05). The larger the tumor was and the later the TNM staging was, along with cancer metastasis, the more likely the expression of E-FABP would dominate. The expression of CRABPII and difference expression between CRABPII and E-FABP were closely related to the prognosis of NSCLC patients based on Kaplan-Meier survival analysis. Conclusion E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC. CRABPII might have a negative effect in NSCLC progression, and its expression was negatively related to the prognosis of NSCLC patients.http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.03Lung neoplasmsCRABPIIE-FABPPrognosisTissue microarrayImmunohistochemistry |
| spellingShingle | Qian LIU Shifeng WANG Huan XU Shangfu ZHANG Expressions and Significances of CRABPII and E-FABP in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms CRABPII E-FABP Prognosis Tissue microarray Immunohistochemistry |
| title | Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung Cancer |
| title_full | Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung Cancer |
| title_fullStr | Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung Cancer |
| title_full_unstemmed | Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung Cancer |
| title_short | Expressions and Significances of CRABPII and E-FABP
in Non-small Cell Lung Cancer |
| title_sort | expressions and significances of crabpii and e fabp
in non small cell lung cancer |
| topic | Lung neoplasms CRABPII E-FABP Prognosis Tissue microarray Immunohistochemistry |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.03 |
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