Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure
Heart failure is an important medical, social and economic problem around the world. In recent years, a number of diagnostic and prognostic biological markers of blood in cardiovascular diseases have been studied. Identification of new biological markers, analysis of their pathophysiological aspects...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2023-01-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1557 |
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| author | A. M. Alieva E. V. Reznik T. V. Pinchuk R. A. Arakelyan R. K. Valiev A. M. Rakhaev A. S. Tikhomirova I. G. Nikitin |
| author_facet | A. M. Alieva E. V. Reznik T. V. Pinchuk R. A. Arakelyan R. K. Valiev A. M. Rakhaev A. S. Tikhomirova I. G. Nikitin |
| author_sort | A. M. Alieva |
| collection | DOAJ |
| description | Heart failure is an important medical, social and economic problem around the world. In recent years, a number of diagnostic and prognostic biological markers of blood in cardiovascular diseases have been studied. Identification of new biological markers, analysis of their pathophysiological aspects and changes in concentration under the influence of various treatment options, allow us to understand many pathogenetic features of the development and course of heart failure. In recent decades, natriuretic peptides have been introduced into clinical practice, which are widely used as reliable markers for diagnostic and prognostic assessment. Growth differentiation factor-15 is a cytokine belonging to the family of transforming growth factors, the activity of which is significantly increased under stress and inflammation. In patients with chronic heart failure, the concentration of this marker is associated with an increased risk of overall mortality and adverse cardiovascular events; in patients with heart failure with preserved left ventricular ejection fraction, the use of the marker showed prognostic and diagnostic significance. Data from the Framingham Heart Study showed that growth differentiation factor-15 was the only marker in multivariate analysis that showed a statistically significant association with all adverse cardiovascular events. Eight studies showed that overexpression of growth differentiation factor-15 was associated with an increased risk of mortality in patients with heart failure. It was shown that growth differentiation factor-15 as a prognostic marker in patients with acute heart failure is not inferior to the brain natriuretic peptide precursor. To confirm the value of this marker in blood in patients with heart failure, it is necessary to conduct extensive prospective randomized clinical trials. |
| first_indexed | 2024-04-10T03:55:51Z |
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| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:51Z |
| publishDate | 2023-01-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-326e873c06bf4b0c913de10b6ef10e8f2023-03-13T07:12:11ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642023-01-01131142310.20514/2226-6704-2023-13-1-14-23925Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart FailureA. M. Alieva0E. V. Reznik1T. V. Pinchuk2R. A. Arakelyan3R. K. Valiev4A. M. Rakhaev5A. S. Tikhomirova6I. G. Nikitin7ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииГБУЗ МКНЦ им. А.С. Логинова ДЗМФедеральное казенное учреждение «Главное бюро медико-социальной экспертизы по кабардино-балкарской республике» Министерства труда и социальной защиты Российской ФедерацииФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России; Федеральное государственное автономное учреждение «Национальный медицинский исследовательский центр «Лечебно-реабилитационный центр» Минздрава РоссииФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России; Федеральное государственное автономное учреждение «Национальный медицинский исследовательский центр «Лечебно-реабилитационный центр» Минздрава РоссииHeart failure is an important medical, social and economic problem around the world. In recent years, a number of diagnostic and prognostic biological markers of blood in cardiovascular diseases have been studied. Identification of new biological markers, analysis of their pathophysiological aspects and changes in concentration under the influence of various treatment options, allow us to understand many pathogenetic features of the development and course of heart failure. In recent decades, natriuretic peptides have been introduced into clinical practice, which are widely used as reliable markers for diagnostic and prognostic assessment. Growth differentiation factor-15 is a cytokine belonging to the family of transforming growth factors, the activity of which is significantly increased under stress and inflammation. In patients with chronic heart failure, the concentration of this marker is associated with an increased risk of overall mortality and adverse cardiovascular events; in patients with heart failure with preserved left ventricular ejection fraction, the use of the marker showed prognostic and diagnostic significance. Data from the Framingham Heart Study showed that growth differentiation factor-15 was the only marker in multivariate analysis that showed a statistically significant association with all adverse cardiovascular events. Eight studies showed that overexpression of growth differentiation factor-15 was associated with an increased risk of mortality in patients with heart failure. It was shown that growth differentiation factor-15 as a prognostic marker in patients with acute heart failure is not inferior to the brain natriuretic peptide precursor. To confirm the value of this marker in blood in patients with heart failure, it is necessary to conduct extensive prospective randomized clinical trials.https://www.medarhive.ru/jour/article/view/1557хроническая сердечная недостаточностьфракция выброса левого желудочкабиомаркерыфактор дифференцировки роста-15 |
| spellingShingle | A. M. Alieva E. V. Reznik T. V. Pinchuk R. A. Arakelyan R. K. Valiev A. M. Rakhaev A. S. Tikhomirova I. G. Nikitin Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure Архивъ внутренней медицины хроническая сердечная недостаточность фракция выброса левого желудочка биомаркеры фактор дифференцировки роста-15 |
| title | Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure |
| title_full | Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure |
| title_fullStr | Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure |
| title_full_unstemmed | Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure |
| title_short | Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure |
| title_sort | growth differentiation factor 15 gdf 15 is a biological marker in heart failure |
| topic | хроническая сердечная недостаточность фракция выброса левого желудочка биомаркеры фактор дифференцировки роста-15 |
| url | https://www.medarhive.ru/jour/article/view/1557 |
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