Single‐Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury

Single‐Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury

Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear is a defining characteristic of PTSD, and the amygdala is considered the main brain region to process fear. The mechanism by which the amygdala is involved in fear conditioning after TBI i...

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Bibliographic Details
Main Authors: Yingwu Shi, Xun Wu, Jinpeng Zhou, Wenxing Cui, Jin Wang, Qing Hu, Shenghao Zhang, Liying Han, Meixuan Zhou, Jianing Luo, Qiang Wang, Haixiao Liu, Dayun Feng, Shunnan Ge, Yan Qu
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Advanced Science
Subjects:
amygdala
decorin
fear conditioning
perineuronal nets
traumatic brain injury
Online Access:https://doi.org/10.1002/advs.202104112

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