Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma
Background: Pancreatic cancer is difficult to diagnose early since tumor markers have low sensitivity and specificity. We simultaneously measured serum carbohydrate antigen (CA) 19-9, pancreatic elastase-1, lipase, and amylase, and evaluated the accuracy of a single marker or a combination of two, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664622002571 |
| _version_ | 1811189515290673152 |
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| author | Chi-Ying Yang Ro-Ting Lin Chi-Yi Chen Chun-Chieh Yeh Chao-Ming Tseng Wen-Hsin Huang Teng-Yu Lee Chia-Shen Chu Jaw-Town Lin |
| author_facet | Chi-Ying Yang Ro-Ting Lin Chi-Yi Chen Chun-Chieh Yeh Chao-Ming Tseng Wen-Hsin Huang Teng-Yu Lee Chia-Shen Chu Jaw-Town Lin |
| author_sort | Chi-Ying Yang |
| collection | DOAJ |
| description | Background: Pancreatic cancer is difficult to diagnose early since tumor markers have low sensitivity and specificity. We simultaneously measured serum carbohydrate antigen (CA) 19-9, pancreatic elastase-1, lipase, and amylase, and evaluated the accuracy of a single marker or a combination of two, three, or four markers in the diagnosis of pancreatic ductal adenocarcinoma (PDAC). Methods: Seventy-six patients with PDAC were included, and 75 patients with non-PDAC diseases were enrolled as the control group. Blood specimens were collected and analyzed for pancreatic elatase-1, CA19-9, amylase and lipase. Sensitivity, specificity, and accuracy for each individual marker and in combination were determined. Results: In PDAC subjects, abnormal CA19-9 was seen most frequently at 80.3%, followed by pancreatic elastase-1 at 57.9%, lipase at 53.9%, and amylase at 51.3%. In non-PDAC subjects, the percentage of abnormal serum pancreatic elastase-1, CA19-9, lipase, and amylase were 50.7%, 41.3%, 40.0%, and 28.0%, respectively. The accuracy rate of amylase and CA19-9 results combined was 64.9% and was higher than the combination of other markers in the intersection set. In the union set, the group of amylase and CA19-9 combined and the group of lipase and CA19-9 combined had the highest accuracy at 66.2%. In the intersection and union set, the area under the curve of CA19-9 was the highest at 0.695. Conclusion: CA19-9 as a single marker is the most accurate in the clinical diagnosis of PDAC. Combination of lipase, amylase, or pancreatic elastase-1 results does not significantly increase the accuracy of PDAC diagnosis. |
| first_indexed | 2024-04-11T14:37:11Z |
| format | Article |
| id | doaj.art-3271927dac30441b8c59df72ab6eb5b8 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-11T14:37:11Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-3271927dac30441b8c59df72ab6eb5b82022-12-22T04:18:18ZengElsevierJournal of the Formosan Medical Association0929-66462022-12-011211226012607Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinomaChi-Ying Yang0Ro-Ting Lin1Chi-Yi Chen2Chun-Chieh Yeh3Chao-Ming Tseng4Wen-Hsin Huang5Teng-Yu Lee6Chia-Shen Chu7Jaw-Town Lin8Department of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, TaiwanDepartment of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, TaiwanDivision of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, TaiwanDepartment of Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Surgery, Asia University Hospital, Taichung, TaiwanDepartment of Internal Medicine, E-DA Hospital, Kaohsiung, TaiwanDepartment of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, TaiwanDepartment of Internal Medicine, E-DA Hospital, Kaohsiung, Taiwan; Corresponding author. Jaw-Town Lin, Department of Internal Medicine, E-DA Hospital. No.1, Yida Road, Yanchao District, Kaohsiung, 82445, Taiwan.Background: Pancreatic cancer is difficult to diagnose early since tumor markers have low sensitivity and specificity. We simultaneously measured serum carbohydrate antigen (CA) 19-9, pancreatic elastase-1, lipase, and amylase, and evaluated the accuracy of a single marker or a combination of two, three, or four markers in the diagnosis of pancreatic ductal adenocarcinoma (PDAC). Methods: Seventy-six patients with PDAC were included, and 75 patients with non-PDAC diseases were enrolled as the control group. Blood specimens were collected and analyzed for pancreatic elatase-1, CA19-9, amylase and lipase. Sensitivity, specificity, and accuracy for each individual marker and in combination were determined. Results: In PDAC subjects, abnormal CA19-9 was seen most frequently at 80.3%, followed by pancreatic elastase-1 at 57.9%, lipase at 53.9%, and amylase at 51.3%. In non-PDAC subjects, the percentage of abnormal serum pancreatic elastase-1, CA19-9, lipase, and amylase were 50.7%, 41.3%, 40.0%, and 28.0%, respectively. The accuracy rate of amylase and CA19-9 results combined was 64.9% and was higher than the combination of other markers in the intersection set. In the union set, the group of amylase and CA19-9 combined and the group of lipase and CA19-9 combined had the highest accuracy at 66.2%. In the intersection and union set, the area under the curve of CA19-9 was the highest at 0.695. Conclusion: CA19-9 as a single marker is the most accurate in the clinical diagnosis of PDAC. Combination of lipase, amylase, or pancreatic elastase-1 results does not significantly increase the accuracy of PDAC diagnosis.http://www.sciencedirect.com/science/article/pii/S0929664622002571AmylaseBiomarkerCA19-9LipasePancreatic elastasePancreatic neoplasms |
| spellingShingle | Chi-Ying Yang Ro-Ting Lin Chi-Yi Chen Chun-Chieh Yeh Chao-Ming Tseng Wen-Hsin Huang Teng-Yu Lee Chia-Shen Chu Jaw-Town Lin Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma Journal of the Formosan Medical Association Amylase Biomarker CA19-9 Lipase Pancreatic elastase Pancreatic neoplasms |
| title | Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma |
| title_full | Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma |
| title_fullStr | Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma |
| title_full_unstemmed | Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma |
| title_short | Accuracy of simultaneous measurement of serum biomarkers: Carbohydrate antigen 19-9, pancreatic elastase-1, amylase, and lipase for diagnosing pancreatic ductal adenocarcinoma |
| title_sort | accuracy of simultaneous measurement of serum biomarkers carbohydrate antigen 19 9 pancreatic elastase 1 amylase and lipase for diagnosing pancreatic ductal adenocarcinoma |
| topic | Amylase Biomarker CA19-9 Lipase Pancreatic elastase Pancreatic neoplasms |
| url | http://www.sciencedirect.com/science/article/pii/S0929664622002571 |
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