| Summary: | The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (non-polar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay.
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