Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs
The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (non-polar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast can...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_07002.pdf |
| _version_ | 1797248931883646976 |
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| author | Megawati Darmawan Akhmad Hudiyono Sumi Permatasari Vera Hidayat Arif Kurniawan Hendris Hendarsyah |
| author_facet | Megawati Darmawan Akhmad Hudiyono Sumi Permatasari Vera Hidayat Arif Kurniawan Hendris Hendarsyah |
| author_sort | Megawati |
| collection | DOAJ |
| description | The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (non-polar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay. |
| first_indexed | 2024-04-24T20:22:26Z |
| format | Article |
| id | doaj.art-3271da8a37354cf5a837fbae2a10656d |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-04-24T20:22:26Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-3271da8a37354cf5a837fbae2a10656d2024-03-22T07:56:07ZengEDP SciencesE3S Web of Conferences2267-12422024-01-015030700210.1051/e3sconf/202450307002e3sconf_isac-iccme2023_07002Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigsMegawati0Darmawan Akhmad1Hudiyono Sumi2Permatasari Vera3Hidayat Arif4Kurniawan Hendris Hendarsyah5Department of Chemistry, Faculty of Mathematics and Natural Sciences (FMIPA), University of IndonesiaResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency of Indonesia (BRIN), KST BJ Habibie, PuspiptekDepartment of Chemistry, Faculty of Mathematics and Natural Sciences (FMIPA), University of IndonesiaResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency of Indonesia (BRIN), KST BJ Habibie, PuspiptekResearch Center for Biosystematics and Evolution, National Research and Innovation Agency of Indonesia (BRIN), Cibinong Science Center, KST SoekarnoResearch Center for Chemistry,National Research and Innovation Agency of Indonesia (BRIN), KST BJ Habibie, PuspiptekThe purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (non-polar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay.https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_07002.pdf |
| spellingShingle | Megawati Darmawan Akhmad Hudiyono Sumi Permatasari Vera Hidayat Arif Kurniawan Hendris Hendarsyah Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs E3S Web of Conferences |
| title | Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs |
| title_full | Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs |
| title_fullStr | Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs |
| title_full_unstemmed | Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs |
| title_short | Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs |
| title_sort | volatile compounds and bioactivities of non polar extracts of horsfieldia macrothyrsa leaves and twigs |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/33/e3sconf_isac-iccme2023_07002.pdf |
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