Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review
Paper-based analytical devices (PADs) have emerged as a promising approach to point-of-care (POC) detection applications in biomedical and clinical diagnosis owing to their advantages, including cost-effectiveness, ease of use, and rapid responses as well as for being equipment-free, disposable, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/5/540 |
| _version_ | 1827692691017695232 |
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| author | Thi Xoan Hoang Le Minh Tu Phan Thuy Anh Thu Vo Sungbo Cho |
| author_facet | Thi Xoan Hoang Le Minh Tu Phan Thuy Anh Thu Vo Sungbo Cho |
| author_sort | Thi Xoan Hoang |
| collection | DOAJ |
| description | Paper-based analytical devices (PADs) have emerged as a promising approach to point-of-care (POC) detection applications in biomedical and clinical diagnosis owing to their advantages, including cost-effectiveness, ease of use, and rapid responses as well as for being equipment-free, disposable, and user-friendly. However, the overall sensitivity of PADs still remains weak, posing a challenge for biosensing scientists exploiting them in clinical applications. This review comprehensively summarizes the current applicable potential of PADs, focusing on total signal-amplification strategies that have been applied widely in PADs involving colorimetry, luminescence, surface-enhanced Raman scattering, photoacoustic, photothermal, and photoelectrochemical methods as well as nucleic acid-mediated PAD modifications. The advances in signal-amplification strategies in terms of signal-enhancing principles, sensitivity, and time reactions are discussed in detail to provide an overview of these approaches to using PADs in biosensing applications. Furthermore, a comparison of these methods summarizes the potential for scientists to develop superior PADs. This review serves as a useful inside look at the current progress and prospective directions in using PADs for clinical diagnostics and provides a better source of reference for further investigations, as well as innovations, in the POC diagnostics field. |
| first_indexed | 2024-03-10T11:28:32Z |
| format | Article |
| id | doaj.art-3272def7e3644a2e9dc97ba64ffc008d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:28:32Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3272def7e3644a2e9dc97ba64ffc008d2023-11-21T19:23:40ZengMDPI AGBiomedicines2227-90592021-05-019554010.3390/biomedicines9050540Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive ReviewThi Xoan Hoang0Le Minh Tu Phan1Thuy Anh Thu Vo2Sungbo Cho3Department of Life Science, Gachon University, Seongnam 13120, Gyeonggi-do, KoreaDepartment of Electronic Engineering, Gachon University, Seongnam 13120, Gyeonggi-do, KoreaDepartment of Life Science, Gachon University, Seongnam 13120, Gyeonggi-do, KoreaDepartment of Electronic Engineering, Gachon University, Seongnam 13120, Gyeonggi-do, KoreaPaper-based analytical devices (PADs) have emerged as a promising approach to point-of-care (POC) detection applications in biomedical and clinical diagnosis owing to their advantages, including cost-effectiveness, ease of use, and rapid responses as well as for being equipment-free, disposable, and user-friendly. However, the overall sensitivity of PADs still remains weak, posing a challenge for biosensing scientists exploiting them in clinical applications. This review comprehensively summarizes the current applicable potential of PADs, focusing on total signal-amplification strategies that have been applied widely in PADs involving colorimetry, luminescence, surface-enhanced Raman scattering, photoacoustic, photothermal, and photoelectrochemical methods as well as nucleic acid-mediated PAD modifications. The advances in signal-amplification strategies in terms of signal-enhancing principles, sensitivity, and time reactions are discussed in detail to provide an overview of these approaches to using PADs in biosensing applications. Furthermore, a comparison of these methods summarizes the potential for scientists to develop superior PADs. This review serves as a useful inside look at the current progress and prospective directions in using PADs for clinical diagnostics and provides a better source of reference for further investigations, as well as innovations, in the POC diagnostics field.https://www.mdpi.com/2227-9059/9/5/540paper-based analytical devicesPADssignal amplificationpoint-of-care diagnostics |
| spellingShingle | Thi Xoan Hoang Le Minh Tu Phan Thuy Anh Thu Vo Sungbo Cho Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review Biomedicines paper-based analytical devices PADs signal amplification point-of-care diagnostics |
| title | Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review |
| title_full | Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review |
| title_fullStr | Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review |
| title_full_unstemmed | Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review |
| title_short | Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review |
| title_sort | advanced signal amplification strategies for paper based analytical devices a comprehensive review |
| topic | paper-based analytical devices PADs signal amplification point-of-care diagnostics |
| url | https://www.mdpi.com/2227-9059/9/5/540 |
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