SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort
Abstract Background The Omicron variant BA.2 was the dominant variant in the COVID-19 outbreak in Shanghai since March 2022. We aim to investigate the characteristics of SARS-CoV-2 Omicron variant infection in pediatric liver-transplanted recipients. Methods We conducted a single-center, prospective...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-023-01978-4 |
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| author | Xin-ye Zhu Ye-feng Lu Feng Xue Yi Luo Ming-xuan Feng Bi-jun Qiu Tao Zhou Jian-jun Zhu Jian-jun Zhang Ping Wan Qiang Xia |
| author_facet | Xin-ye Zhu Ye-feng Lu Feng Xue Yi Luo Ming-xuan Feng Bi-jun Qiu Tao Zhou Jian-jun Zhu Jian-jun Zhang Ping Wan Qiang Xia |
| author_sort | Xin-ye Zhu |
| collection | DOAJ |
| description | Abstract Background The Omicron variant BA.2 was the dominant variant in the COVID-19 outbreak in Shanghai since March 2022. We aim to investigate the characteristics of SARS-CoV-2 Omicron variant infection in pediatric liver-transplanted recipients. Methods We conducted a single-center, prospective, observational, single-arm study. We enrolled pediatric liver-transplanted patients infected with the Omicron variant BA.2 from March 19th to October 1st, 2022 and analyzed their demographic, clinical, laboratory, and outcome data. The management of COVID-19 was conducted according to the 9th trial edition of the Chinese guideline. The immunosuppressive therapy was tailored considering the patients’ infection developments and liver functions. Results Five children were included. The primary diseases included Niemann-Pick disease, propionic acidemia, decompensated cirrhosis, biliary atresia, and Crigler-Najjar syndrome type I. All of the patients were onset with fever before or when getting RNA-positive results at the age of 3 (Range: 1–13) years. The infection duration was 29 (Range: 18–40) days. Three and two children were diagnosed with mild and moderate COVID-19 respectively. Two patients were tested RNA-positive within 14 days after having been tested negative. The immunosuppressants were paused or extenuated in four patients. Eight of all nine cohabitants were injected with at least two doses of inactivated SARS-CoV-2 vaccine. The disease courses were significantly longer than the patients (P < 0.05). Conclusions Post-transplant immunosuppression slows down the virus clearance and increases the risk of relapse but does not affect symptom duration or infection severity in pediatric patients. Patients can usually gain a favorable outcome and prognosis by extenuating immunosuppressants. |
| first_indexed | 2024-04-10T15:46:08Z |
| format | Article |
| id | doaj.art-3273fd5efebf4c9a9f0533329e66130b |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-10T15:46:08Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-3273fd5efebf4c9a9f0533329e66130b2023-02-12T12:04:33ZengBMCVirology Journal1743-422X2023-02-0120111210.1186/s12985-023-01978-4SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohortXin-ye Zhu0Ye-feng Lu1Feng Xue2Yi Luo3Ming-xuan Feng4Bi-jun Qiu5Tao Zhou6Jian-jun Zhu7Jian-jun Zhang8Ping Wan9Qiang Xia10Department of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background The Omicron variant BA.2 was the dominant variant in the COVID-19 outbreak in Shanghai since March 2022. We aim to investigate the characteristics of SARS-CoV-2 Omicron variant infection in pediatric liver-transplanted recipients. Methods We conducted a single-center, prospective, observational, single-arm study. We enrolled pediatric liver-transplanted patients infected with the Omicron variant BA.2 from March 19th to October 1st, 2022 and analyzed their demographic, clinical, laboratory, and outcome data. The management of COVID-19 was conducted according to the 9th trial edition of the Chinese guideline. The immunosuppressive therapy was tailored considering the patients’ infection developments and liver functions. Results Five children were included. The primary diseases included Niemann-Pick disease, propionic acidemia, decompensated cirrhosis, biliary atresia, and Crigler-Najjar syndrome type I. All of the patients were onset with fever before or when getting RNA-positive results at the age of 3 (Range: 1–13) years. The infection duration was 29 (Range: 18–40) days. Three and two children were diagnosed with mild and moderate COVID-19 respectively. Two patients were tested RNA-positive within 14 days after having been tested negative. The immunosuppressants were paused or extenuated in four patients. Eight of all nine cohabitants were injected with at least two doses of inactivated SARS-CoV-2 vaccine. The disease courses were significantly longer than the patients (P < 0.05). Conclusions Post-transplant immunosuppression slows down the virus clearance and increases the risk of relapse but does not affect symptom duration or infection severity in pediatric patients. Patients can usually gain a favorable outcome and prognosis by extenuating immunosuppressants.https://doi.org/10.1186/s12985-023-01978-4ChildrenImmunosuppressionLiver transplantationSARS‐CoV‐2Solid organ |
| spellingShingle | Xin-ye Zhu Ye-feng Lu Feng Xue Yi Luo Ming-xuan Feng Bi-jun Qiu Tao Zhou Jian-jun Zhu Jian-jun Zhang Ping Wan Qiang Xia SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort Virology Journal Children Immunosuppression Liver transplantation SARS‐CoV‐2 Solid organ |
| title | SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort |
| title_full | SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort |
| title_fullStr | SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort |
| title_full_unstemmed | SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort |
| title_short | SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort |
| title_sort | sars cov 2 ba 2 omicron variant infection in pediatric liver transplanted recipients and cohabitants during 2022 shanghai outbreak a prospective cohort |
| topic | Children Immunosuppression Liver transplantation SARS‐CoV‐2 Solid organ |
| url | https://doi.org/10.1186/s12985-023-01978-4 |
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