HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
Abstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-01-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-016-0001-0 |
| _version_ | 1818749298573049856 |
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| author | Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators |
| author_facet | Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators |
| author_sort | Kazuharu Furutani |
| collection | DOAJ |
| description | Abstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research. |
| first_indexed | 2024-12-18T04:01:34Z |
| format | Article |
| id | doaj.art-32749499b1454f07b3e40ab76fdeecb7 |
| institution | Directory Open Access Journal |
| issn | 2056-7189 |
| language | English |
| last_indexed | 2024-12-18T04:01:34Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj.art-32749499b1454f07b3e40ab76fdeecb72022-12-21T21:21:40ZengNature Portfolionpj Systems Biology and Applications2056-71892017-01-01311710.1038/s41540-016-0001-0HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome researchKazuharu Furutani0Kunichika Tsumoto1Yoshihisa Kurachi2for HD physiology project investigators3Department of Pharmacology, Graduate School of Medicine, Osaka UniversityDepartment of Pharmacology, Graduate School of Medicine, Osaka UniversityDepartment of Pharmacology, Graduate School of Medicine, Osaka UniversityHD Physiology ProjectAbstract The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.https://doi.org/10.1038/s41540-016-0001-0 |
| spellingShingle | Kazuharu Furutani Kunichika Tsumoto Yoshihisa Kurachi for HD physiology project investigators HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research npj Systems Biology and Applications |
| title | HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research |
| title_full | HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research |
| title_fullStr | HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research |
| title_full_unstemmed | HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research |
| title_short | HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research |
| title_sort | hd physiology project japanese efforts to promote multilevel integrative systems biology and physiome research |
| url | https://doi.org/10.1038/s41540-016-0001-0 |
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